Valcyte - an antiviral drug.
Pharmacological action Valtsita
The active ingredient of the drug Valcyte - valganciclovir suppressing cytomegalovirus, herpes simplex 1 and 2 types of human herpes 6, 7, 8 types of the hepatitis B virus, Epstein-Barr virus, varicella zoster.
Valcyte release tablets.
Valcyte is used to treat CMV retinitis (disease of the retina) in AIDS patients and to prevent infection in transplant patients.
Taking Valcyte with food.
Patients with active CMV retinitis give 900mg of the drug two p / day. The therapy lasts 21 days. During maintenance treatment take Valcyte one p / day - 900mg. Then if the disease gets worse, enhanced treatment is repeated.
According to the instructions for Valcyte prophylaxis of cytomegalovirus after an organ transplant to take prescribed at a dose of 900mg a p / day. Treatment continued from 10 to 100 days after transplantation of organs.
Patients with renal insufficiency Valcyte administered depending on creatinine clearance. If it is more than 60ml / min, the drug is prescribed by the standard procedure; If 40-59ml / min - should take two 450mg Valtsita p / day; when clearance 25-39ml / min - one 450mg p / day and 450mg every two days; when clearance 10-24ml / min - 450mg every two days and an additional two rows of 450mg / week.
Valcyte in patients with AIDS and CMV retinitis can cause neutropenia, fever, diarrhea, weakness, oral candidiasis, headache.
Patients after organ transplantation drug can cause diarrhea, nausea, leukopenia, neutropenia, high blood pressure, liver dysfunction, hyperkalemia.
Common side effects Valtsita arising in patients with CMV retinitis and survivors of organ transplantation: nausea, flatulence, diarrhea, constipation, vomiting, abdominal pain, ascites, oral candidiasis, abnormal liver function.
Besides Valcyte may cause leukopenia
, night sweats
, shortness of breath
, nasal discharge
, pleural effusion
, blurred vision
, renal failure
, urinary duct
, reduction or decrease in pressure
, swelling of the feet
, weight loss
, reaction of rejection of the transplanted organ
, poor appetite
, mental disorders
, dry mouth
, ulcerative stomatitis
, bleeding from the gastrointestinal tract
, dysfunction of the gastrointestinal tract
, bacterial and fungal infections
With an overdose of Valcyte leads to: leukopenia, pancytopenia, bone marrow suppression, medullary aplasia, granulocytopenia, neutropenia, hepatotoxicity, nephrotoxicity, neurotoxicity. Treat poisoning dialysis and hydration.
Valcyte is not indicated by the instructions, if the index is less than 500mkl neutropenia, hemoglobin - less than 80g / l, thrombocytopenia - less than 25,000 l if severe renal insufficiency and creatinine clearance less than 10 ml / min.
Valcyte is contraindicated in children up to 12l, lactating and pregnant women.
With care elderly patients taking the drug and those who suffer from renal insufficiency.