Uregei - diuretic.
Pharmacological action Uregita
the drug substance - ethacrynic acid. She quickly has a pronounced diuretic effect, regardless of the acid-alkaline balance. It is effective and alkalosis and acidosis. The point of application Uregita at nephron - ascending portion of Henle's loop, proximal and distal renal tubules, so it belongs to the group of loop diuretics. He has almost no effect on renal blood flow and glomerular filtration, except in cases of reduction of liquid due to a too large increase in urine output. In these cases Uregei reduces systemic arterial pressure. Its mechanism of action is inhibition of the active transport of chloride ions and sodium in the nephron. This is accompanied by an increased loss of potassium, which is necessary to compensate for the diuretic at the same time taking potassium containing drugs.
Compared with thiazide diuretic effect Uregita analogues of the drug is expressed in a few times more, since ethacrynic acid inhibits the reabsorption of sodium in the renal tubules is much stronger, which allows the use of the drug for renal failure. The effect is dose-dependent and Uregita directly related to the degree of water retention in the body.
If you take the drug for a long time, it decreases the excretion of chloride ions and potassium ions and hydrogen on the contrary, may increase.
Uregei well absorbed from the digestive tract, bioavailability it is 100%. The diuretic action begins half an hour after administration, reaching a maximum after 2 hours and lasts up to 8 hours. The liver is carried Uregita conjugation, excreted from the body, he urine and feces, in part unaltered.
Uregei available in tablets of 50 mg.
According to the instructions Uregei prescribed for edema of different origin - renal, cardiac, traumatic, in portal hypertension. In the case of ineffectiveness or other thiazide analogues Uregita it is also a diuretic of choice.
Do not use the drug in case of a complete lack of urine - anuria, expressed in violation of the acid-base and water balance, hepatic coma, lactose intolerance, the enzyme lactase deficiency during pregnancy and breastfeeding to the age of 2 years, in case of intolerance of components. Carefully apply this tool in the elderly, with primary hyperaldosteronism (irregularities in the adrenal cortex), and connective tissue diseases (eg, systemic lupus erythematosus).
Instructions for use Uregita
According to the instructions Uregei taken orally once a day 1, the morning after breakfast, drinking water. Before treatment should clarify the functional state of the liver and kidneys. Begin therapy at a dose of 50 mg / day (one tablet), if necessary, gradually increasing it until the desired effect, but not more than 200 mg / day (4 tablets). The recommended dose should be lower, causing a gradual weight loss of 0, 5 - 1 kg / day.
During treatment requires
level control diuresis. The maintenance dose is on average 25 - 200 mg / day, for example skipping a few doses to maintain the activity of the drug. For example, you can use Uregei skipping 1 - 3 days between doses. Older people need a smaller dose to achieve the diuretic effect.
Children older than 2 years Uregei prescribed for short periods only in the hospital for 25 mg / day in the nephrotic syndrome or congenital heart disease.
Allowed combination with the drug-analogue Uregita from other pharmacological groups diuretics.
Uregei often causes violations of water-electrolyte balance (excessive loss of potassium, sodium, water, alkalosis, increased levels of uric acid). There are unpleasant symptoms such as abdominal pain, vomiting, diarrhea, tinnitus and hearing loss, blurred vision, headaches, changes in the blood count (reduced platelet count, absence of neutrophils), skin rashes, fever.