International name Tsipromeda: ciprofloxacin (Ciprofloxacin)  Ear drops Tsipromed

Composition Tsipromeda

Active ingredient: ciprofloxacin hydrochloride. As auxiliary substances are used: water for injection, disodium edetate, sodium hydroxide, lactic acid, benzalkonium chloride, sodium chloride.

Pharmacological action

Tsipromed - antimicrobial agent belonging to the group of fluoroquinolones, used in ophthalmology for local action. It has a wide antimicrobial activity, it is a bactericidal agent. Tsipromed low toxicity.

Effect of the drug is due to its property to inhibit enzymes (DNA gyrase) bacteria, thereby disrupting DNA replication and synthesis of cellular proteins of bacteria. Action Tsipromeda applies to both microbes and on being in the resting stage. Ciprofloxacin hydrochloride from gram-negative aerobic bacteria are sensitive:

  • enterobacteria - Salmonella spp., Hafnia alvei, Yersinia spp., Morganella morganii, Edwardsiella tarda, Citrobacter spp., Proteus vulgaris, Enterobacter spp., Vibrio spp., Proteus mirabilis;
  • al. Gram - Aeromonas spp., Haemophilus spp., Pasteurella multocida, Moraxella catarrhalis, Plesiomonas shigelloides, Neisseria spp., Campylobacter jejuni;
  • certain intracellular pathogens - Brucella spp., Mycobacterium tuberculosis, Mycobacterium kansasii, Legionella pneumophila, Listeria monocytogenes, Chlamydia trachomatis;
  • Gram positive bacteria: Staphylococcus spp., Streptococcus spp.

The majority of methicillin-resistant staphylococci are resistant to ciprofloxacin. The sensitivity of Mycobacterium avium, Streptococcus pneumoniae - moderate (to neutralize requires high concentration). Resistant to ciprofloxacin: Pseudomonas maltophilia, Bacteroides fragilis, Nocardia asteroides, Ureaplasma urealyticum, Pseudomonas cepacia.

Pharmacokinetics Tsipromeda

When applied topically Tsipromed easily penetrates into the tissue of the eye. For a single application of the drug, its concentration in the ophthalmic camera moisture after 10 minutes was 100 ug / ml. The maximum concentration is achieved after 1 hour is 190mkg / ml. After 2:00 drug concentration begins to decrease, while anti-bacterial effect continues in the tissue of the cornea about 6 hours.

When the seven-day treatment with the use of eye drops fourfold Tsipromed average concentration of less than 2ng / ml.

The half-life of the drug for 4-5 hours. Tsipromed excreted by the kidneys unchanged - 50%, in the form of metabolites - 10% through the gut of about 15%. A small portion of the drug may get into breast milk.

The dosage of eye drops Tsipromed and instructions for use

The drug is used topically, 1-2 drops into the conjunctival sac of the eye. The frequency of the drug is on average 4 hours, but can vary depending on the severity of inflammation.

In acute conjunctivitis Tsipromed assigned 4-8 times a day. The course of treatment 5-14 days.

If keratitis Tsipromed assigned at least 6 times a day. The duration of therapy depends on the extent of the eye. The average course of therapy is 2-4 weeks.

When lesions caused by Pseudomonas aeruginosa, Tsipromed prescribed 1 drop of 8-12 times a day. Duration of therapy is determined depending on the course of treatment, usually about 2-3 days.

For the prevention of secondary infections resulting from trauma to the eye, the drug is administered 1 drop 8 times per day for 1-2 weeks.

For the prevention of inflammatory processes in the post-operative period (Steps perforated eyeball) assigned Tsipromed 1 drop of 4 to 6 times a day, during the rehabilitation period - from 5 days to 1 month.  Eye drops Tsipromed


In case of accidental internal use Tsipromeda reviews of specific symptoms has not been fixed. Possible reactions such as nausea, diarrhea, vomiting, fainting, headache, anxiety.

As treatment of overdose Tsipromedom instructions recommended standard first aid measures as well as providing the body fluid.

Interaction with other drugs Tsipromeda

Tsipromed compatible with the drugs, the pH value of which is equal to 3-4.

Indications Tsipromeda

The drug is used to treat:

  • infectious and inflammatory processes in the eye and its appendages, provoked by bacteria susceptible to the drug;
  • acute and subacute conjunctivitis;
  • anterior uveitis;
  • dacryocystitis;
  • keratitis;
  • blepharitis and other inflammatory diseases of the eyelids.

And Tsipromed used for the prevention and treatment of infectious complications in the post-operations on the eyeball and eye injuries.

Tsipromed contraindicated

  • children under 1 year;
  • if you are hypersensitive fluoroquinolones;
  • pregnant women;
  • breastfeeding.

Pregnancy and lactation

Application contraindicated in pregnancy.

When the need for therapy Tsipromedom breastfeeding should be discontinued.

Side effects Tsipromeda

The drug Tsipromed may cause the following side effects: itching, transient burning sensation, pain, flushing of the eye mucosa, allergic reactions, photophobia, eyelid edema, foreign body sensation in the eye, staining, lacrimation, blurred vision, keratitis, development of superinfection . According to the reviews, tsipromed immediately after installation can cause a feeling of unpleasant taste in the mouth.


It is not recommended to use eye drops Tsipromed simultaneously with wearing soft contact lenses. Part of the Tsipromeda preservative may be delayed on the lenses and then adversely affect the eyes. Instruction Tsipromeda allowed to use the drug to persons wearing hard contact lenses. In advance before the installation of the preparation, remove hard contact lenses, and place them back at least 15 minutes after administration.

When combined therapy with other ophthalmic drugs pause between their intake should be at least 5 minutes.

Obtained using Tsipromeda reviews have shown that the drug can cause a short-term decrease in visual acuity, and cause slowing of psychomotor reactions, especially in combination with alcohol. This fact should be taken into account by persons engaged in potentially dangerous activities that require concentration, including driving vehicles.

Storage conditions Tsipromeda

Tsipromed should be stored at room temperature, without freezing, out of the reach of children.

Storage life

2 years. After depressurization of the drug manufacturer's packaging is kept less than 1 month.