Trombless - local anticoagulant agent.
According to the instructions Trombless contains in its structure active substance - heparin. According to the mechanism
Heparin acts belong to the group of direct anticoagulants. It affects blood clotting, increasing its fibrinolytic properties. This is realized by the fact that heparin binds with antithrombin III and blocks passage of prothrombin into thrombin and also inhibits the activity of thrombin. Trombless reduces adhesion of platelets to each other and to the vessel wall, hyaluronidase lowers the enzymatic activity and thus improves circulation to the smallest blood vessels of the circulatory system. Because of this and improves tissue nutrition.
Due to the fact that the drug improves microcirculation, faster dissolve subcutaneous hematoma and blood clots peripheral veins, which restores patency of veins. Due to the fact that the extremities eliminated venous stasis, they swell less. So implemented anti-inflammatory, analgesic, and anti-proliferative effects Tromblessa. Antiseptic alcohol based gel creates a cooling effect, which also eliminates the weight and pain in the legs.
This mechanism of action has Tromblessa and analogues based on heparin - Lioton gels, heparin-Akrigel, Lavenum.
The drug applied to the skin surface, its absorption into the blood is minimal, and thus no risk of overdosing of heparin and related complications. The shape of the gel allows faster and more efficiently penetrate the layers of skin heparin than from an ointment. The amount of gel entering the active substance has a dose-dependent effect.
The heparin transformed liver to inactive metabolites. Metabolites excretion through the kidneys.
Form release Tromblessa
Trombless made in the form of a gel for application to the skin. 1 g of gel (strip 1 cm) contains 1000 units of heparin.
According to the instructions he had indicated in thrombosis and inflammation of the superficial veins (thrombophlebitis) and the associated swelling of the surrounding tissues. Good reviews Trombless received treatment injuries and injuries of soft tissues and joints. It is effective for preventing and treating varicose veins.
this means in the case of hypersensitivity to its components, a tendency to bleeding, in violation of the integrity of the skin, as well as ulcers and necrotic lesions of it.
Like its counterparts Trombless not recommended for use in conjunction with local nonsteroidal anti-inflammatory, anti-histamine and tetracycline ointment.
The drug can be used during pregnancy and lactation.
Instructions for use Tromblessa
The gel was applied to the surface with a clean dry intact skin. The strip of gel length of 3 - 10 cm is applied to the affected area, rub with light massaging movements from 1 to 3 times a day every day. The course of treatment lasts on average 3 - 7 days.
If during use inside Tromblessa assigned indirect anticoagulants (warfarin, Fenilin), there may be changes in coagulogram, in particular, the elongation of prothrombin time.
In the opinion of Trombless with prolonged application can sometimes cause allergic reactions or redness at the site of application.