Tritatse (tritase) - antihypertensive drug, an angiotensin-converting enzyme.
Pharmacological action Tritatse
The active substance Tritatse - ramipril, the oral route reduces the formation of angiotensin II, the accumulation of bradykinin, which causes vasodilation and lowering blood pressure. Ramipril has a cardioprotective effect and endotelioprotektornoe increases prostaglandin synthesis, increases the serum concentration of potassium ions, reduces the secretion of aldosterone, the risk of the occurrence of microalbuminuria and nephropathy.
Form release Tritatse
Tritatse produced in the form of oblong tablets with dividing line:
Light yellow marked "2, 5h» one and "2, 5 / HMR» on the other hand to the blisters 14 pcs. in cardboard packages, whose composition per 1 tablet includes 2, 5 mg ramipril;
Light pink with a few splashes of lighter and darker shades with an engraving «5h» one and "5HMR" on the other side in blister packs of 14 pieces. in cardboard packages, whose composition per 1 tablet includes 5 mg ramipril;
White or nearly white engraved «HMO / HMO» on one side in blisters on 14 pcs. in cardboard packages, whose composition per 1 tablet comprises 10 mg of ramipril.
Tritatse analogues of the active substance are:
By analogues Tritatse mechanism of action and of belonging to a pharmacological group includes:
In accordance with the instructions Tritatse prescribed for:
Combination therapy of chronic heart failure (in combination with a diuretic);
Diabetes or nondiabetic nephropathy;
Confirmed coronary heart disease;
Peripheral arterial occlusive disease;
Diabetes mellitus with additional risk factors;
Heart failure develops over the first few days after an acute myocardial infarction.
In accordance with the instructions Tritatse Inside, regardless of meals, plenty of drinking water. The duration of treatment and the dosage depends on the disease and are prescribed individually.
According to the instructions Tritatse contraindicated to apply at:
Hemodynamically significant renal artery stenosis, aortic or mitral valves;
Hypotension and conditions;
Unstable hemodynamic parameters;
Obstructive hypertrophic cardiomyopathy;
Pregnancy and lactation;
Chronic heart failure decompensation stage;
Hypersensitivity to the tablets Tritatse;
Acute phase of myocardial infarction (severe heart failure, unstable angina, cardiac arrhythmias, and pulmonary heart).
Also according to the instructions Tritatse prescribed with caution in the case of:
A condition in which blood pressure reduction is particularly dangerous;
States, accompanied by increased activity of the hormone system;
Disorders of water and electrolyte balance;
Abnormal liver function;
Cirrhosis of the liver accompanied by edema and ascites;
Systemic connective tissue diseases;
The drug is not intended for use for children under the age of 18 years and with care in the elderly people.
Side effects Tritatse
Application of Tritatse reviews can lead to complications of the various systems of the body in cases of overdose. For part of the Review of Tritatse often cause conjunctivitis and visual disorders, hearing - ringing in the ears or hearing impairment. In addition, drug overdose may cause other disorders, namely
Central nervous system (headache, dizziness, ageusia, dysgeusia, depressed mood, anxiety, nervousness, sleep disorders, attention and psychomotor reactions, tremor, cerebral ischemia, paresthesia and parosmiya);
Respiratory system (a dry cough, bronchitis, shortness of breath, sinusitis, nasal congestion and bronchospasm);
Digestive system (inflammation of the stomach and intestines, dry mucous membranes of the mouth, indigestion, dyspepsia, diarrhea, nausea, vomiting, pancreatitis, gastritis, abdominal pain, constipation, glossitis, aphthous stomatitis);
Hepatobiliary system (increasing the concentration of conjugated bilirubin in the blood plasma and liver enzymes, cholestatic jaundice, hepatocellular injury, acute liver failure, cytolytic and cholestatic hepatitis);
Kidney and urinary tract (renal failure and renal failure, increased urination, increased proteinuria, increased concentrations of urea and creatinine in the blood);
Breast and reproductive system (impotence, decreased libido, and gynecomastia);
Hematopoietic system (eosinophilia, leucopenia, decreased hemoglobin concentration and erythrocyte count in the peripheral blood, thrombocytopenia, inhibition of bone marrow blood and haemolytic anemia);
Mucous membranes and skin (skin rash, angioedema, pruritus, rash, exfoliative dermatitis, urticaria, onycholysis, photosensitivity reactions, Stevens-Johnson syndrome, psoriasiform dermatitis, toxic epidermal necrolysis, pemphigus, alopecia, erythritol multiforme, increased flow of psoriasis pemfigoidnuyu and lichenoid ekzatemu or enanth);
Musculoskeletal system (muscle spasms, myalgia, arthralgia, disorders of laboratory parameters, nutrition and metabolism, increasing the concentration of potassium in the blood, anorexia, decreased appetite and concentration of sodium in the blood);
Immune system (anaphylactoid and anaphylactic reactions, increasing the concentration of antinuclear antibodies).
Also, the use of Tritatse reviews can lead to chest pain, fatigue, fever and fatigue.
In accordance with the instructions Tritatse should be stored out of the reach of children, at room temperature to 25 ° C. Shelf life of the drug is 5 years.