Trigrim belongs to diuretics.
Composition, structure and packing
The instructions to Trigrimu said that the medicament is manufactured as a round, biconvex tablet white. 2 one tablet contains 5 mg of torasemide. Additional substances belong corn starch, magnesium stearate, lactose, colloidal silicon dioxide.
Also make Trigrim as white, round, flat tablets, which have a long centered risk. 1 tablet contains 5 mg or 10 mg of torasemide. Additional components belong corn starch, magnesium stearate, lactose, colloidal silicon dioxide.
In pharmacies sold in the form of blisters of 10 pieces.
Pharmacological action Trigrima
Instruction Trigrimu shows that the analyzed drug and analogs Trigrima belong to the group of diuretics. The principle of operation is explained tablets torasemide connection with kontransporterom Na + / 2Cl- / K +, which is located in the apical membrane of the thick ascending segment of the loop of Henle. It therefore can be said that the human body is reduced significantly or almost completely slows and prevents reabsorption of sodium ions. The result of this process is the reduction of the osmotic pressure of the intracellular fluid and water reabsorption.
The feedback to the Trigrimu noted that the drug, due to its antialdosterone action, which is much less pronounced than that of furosemide, almost provoking hypokalemia, despite their more active ingredients and prolonged action.
- Edema associated with kidney disease, liver, heart;
- Hypertension is the first degree.
Anuria, arrhythmia, during pregnancy and lactation, chronic renal failure, and hypersensitivity to individual components Trigrima.
Require further consultations, patients with diabetes, liver disease, gout.
Dosing and dosing regimen Trigrima
The instructions to Trigrimu said that the drug, as well as analogs Trigrima taken orally. Assign Trigrim adults. Permission is granted to use the tablets before or during the meal.
If the patient has edema, in this case the drug prescribed 5 mg of no more than 1 time per day. If absolutely necessary, the dosage may be increased to 20 mg (this should be done gradually) 1 times a day. In some cases, should be used Trigrim to 40 mg in 24 hours.
If the patient is found edema, cause of which is associated with congestive heart failure, the expert prescribes such a patient of from 5 to 20 mg per day. As stated in the instruction to Trigrimu under the supervision of a medical worker, the dosage may be gradually increased to a maximum of 200 mg.
When edema, the cause of which is associated with chronic renal failure, especially prescribe 20 mg per day of the analyzed funds. If there is an acute need, then the dosage is gradually increased (maximum 200 mg over 24 hours). This is done to achieve the best diuretic effect.
When edema, which are directly associated with cirrhosis of the liver, patients prescribed daily dose in a volume of 5-10 mg. In some cases, the dose may be doubled (this should be done gradually), which allows to reach the best diuretic effect. Until now, no time to conduct medical research that might say about the possible consequences arising in patients taking more than 40 mg of the drug in liver disease.
If the patient has a primary hypertension, it being prescribed two 5 mg per day. Increasing the dose to 5 mg, blood pressure remains unchanged. The maximum effect of treatment occurs after only 12 weeks.
The feedback to the Trigrimu noted that elderly patients do not need more advice about dosage and analogues Trigrima.
- Increased urine output, which entails hypovolemia, electrolyte imbalance;
- The decrease in blood pressure, drowsiness;
- The collapse;
- Malfunctions of the gastrointestinal tract.
The most effective method of treatment is to reduce the dosage or complete removal of the drug for the individual patient. Special antidote to date there.
Drug interaction Trigrima
When receiving Trigrima significantly increases the perception myocardial cardiac glycosides, if this is not enough in the body, calcium and potassium. If you take Trigrim or analogs Trigrima with laxatives or corticosteroids, that can amplify the process of excretion of potassium.
When used with antihypertensive drugs analyzed drug enhances their effect on the body. When receiving Trigrima in higher doses, may increase the toxic effects of a number of drugs (cisplatin, antibiotics).
Taking salicylates in high doses, there is an increase in their toxic interaction on the body. Step antidiabetic drugs become weaker, as well as some vasoconstrictor (e.g. epinephrine and norepinephrine).
NSAIDs in some cases, reduce the effect of antihypertensive and diuretic Trigrima. Action kolestiramina sometimes provokes a decrease of torasemide absorbability from the digestive system (it is confirmed by numerous experiments conducted on animals).
Side effects Trigrima
The feedback to the Trigrimu noted that among the most common side effects after taking this drug observed decrease in the concentration of white blood cells, red blood cells and platelets.
In some cases there is an increase in serum uric acid, lipids, and even glucose. It may also occur hypokalemia. Very rarely there are disruptions in the normal circulation of the blood, impaired blood pressure.
Reviews Trigrimu to show that there are often problems with the gastrointestinal tract, decreased appetite, and discomfort in the mouth. Quite rare - pancreatitis and increased liver enzymes, urinary retention, and an increase in serum creatinine and urea in plasma.
There are also frequent severe headaches, weakness, dizziness, confusion, drowsiness, cramps in arms and legs, impaired hearing, vision, and complete deafness, itching and skin rashes.
Conditions and terms of Trigrima
Keep away from children at a temperature of 25 degrees. Shelf life is not more than 3 years.
Due to the lack of appropriate experiments is not recommended to give Trigrim children under 18 years. At long reception drug should be examination of the body relative to the level of glucose, lipid and uric acid. In the presence of hypokalemia, hypovolemia Trigrim should be taken only after the complete elimination of the symptoms of these diseases.