Triamcinolone - hormonal drug group glucocorticoids.
The pharmacological action of Triamcinolone
Triamcinolone is used as an antiallergic, immunosuppressive, anti-inflammatory agents and glucocorticoid. The therapeutic effect of taking Triamcinolone achieved by suppressing properties of tissue macrophages, leukocytes, fibroblasts and collagen formation. Effect of the drug intended to limit migration of leukocytes to inflammation and impaired ability of macrophages to phagocytosis. Besides Triamcinolone stabilizes lysosomal membranes, which entails reduction in the concentration of proteolytic enzymes in the inflamed area of the body.
Trimatsinolon has a stimulating effect on gluconeogenesis, increasing the activity of enzymes involved in it. In addition, it acts as a catalyst in muscle, bone, skin, connective, and lymphoid tissues, adipose tissue.
Triamcinolone is available in tablet form mass 4 mg; 0, 1% ointment and cream mass 5 or '10
Instruction triamcinolone recommends various preparation forms depending on the specific disease.
Tablets should be taken in such cases as rheumatoid arthritis and rheumatism, collagen diseases (including systemic lupus erythematosus), severe allergic reactions, skin diseases caused by allergies, asthma severe hemolytic anemia, hemorrhagic diathesis, erythema multiforme, leukemia and lymphoma ;
In the form of inhaled triamcinolone should be used in asthma exacerbation, allergic rhinitis, asthma, hormone-dependent;
Parenteral administration Triamcinolone possible for rheumatoid arthritis, connective tissue diseases, dermatosis, systemic lupus erythematosus, emphysema or pulmonary fibrosis, lymphosarcoma, lymphatic leukemia, Hodgkin disease, nephrotic syndrome;
External application of Triamcinolone recommended for eczema, psoriasis, atopic dermatitis, dermatitis of various kinds, as well as other allergic and inflammatory skin diseases nemikrobnoy etiology as part of the combined therapy.
Triamcinolone is not recommended for patients prone to the following diseases:
acute psychosis in history;
tuberculosis in active form;
duodenal ulcer and / or stomach;
transferred thrombosis and embolism;
hidden pockets of infection;
fungal and viral infections (including herpes);
polio (except bulbar-encephalitic form);
arthritis (gonococcal and tuberculosis);
lymphadenitis after BCG;
Instructions for use Triamcinolone
According to the instructions to triamcinolone, the drug should be taken in the following dosages.
Inside adults recommended from 4 to 20 mg per day, the frequency of reception - 2-3. Upon the occurrence of improving the daily dose of Triamcinolone reduced to 2 mg to be taken every 2-3 days. Subsequently, the dose is reduced to a maintenance 1 mg per day, and then - the complete abolition of therapy;
at / m Triamcinolone administration the dosage is 40 mg once every 4 weeks. Subsequently, focusing on the physician and patient tolerability of the drug, the dosage may be increased up to 80 mg every 2-4 weeks. If necessary, the dose may be increased to 100 mg. The drug should be injected deep into the muscle, thereby avoiding subcutaneous atrophy;
dosage Triamcinolone when intraarticular injection or administered to the lesion is 10 to 40 mg every week;
dose inhalation drug is calculated from the patient's age and chosen form of Triamcinolone for the procedure;
Triamcinolone usage when applied topically should not exceed three times a day. The duration of treatment generally do not exceed 10 days and determined individually. In rare cases, the treatment is extended up to 25 days, but it is not recommended to use the drug more than 4 weeks.
Side effects Triamcinolone
Before taking Triamcinolone is recommended to check the list of side effects in order to avoid complications in the future. In some cases, the application is accompanied by Triamcinolone:
menstrual irregularities, the redistribution of body fat, increased levels of blood glucose, adrenal suppression, the advent of "crescent-shaped face." You may also experience stretch marks, acne, hirsutism;
edema, electrolyte imbalance, negative nitrogen balance, growth retardation in children;
steroid stomach ulcer, acute pancreatitis, erosive and ulcerative lesions of the gastrointestinal tract;
convulsions, sleep disorders and mental disorders, headaches, weakness;
In addition, specific side effects for each method of application Triamcinolone:
intra-articular administration may lead to the emergence of joint pain, irritation at the injection site sterile abscess, depigmentation, skin atrophy;
Inhalation may be side effects such as sneezing, coughing, headache, dry membranes of the nose or mouth, hoarseness, fungal infections such as the appearance of Candida albicans;
external use of the drug can cause itching, eczema, skin irritation, and purpura steroid acne. Prolonged use of ointment is fraught with the development of atrophic changes of the skin and secondary infections signs.
Note that triamcinolone is not intended for in / in the introduction.
Not recommended parenteral use in children, whose age is 6 years old or less. Children from 6 to 12 years this method of use of the drug should be administered in extreme cases.