Topamax (international name - Topiramate) refers to a group of anticonvulsant drugs which block sodium receptors stop
nervous excitement and relieve spasms. The drug is effective for the treatment of epilepsy syndrome, migraine, tonic-clonic seizures and Lennox-Gastaut syndrome.
Structure and Composition
The main active ingredient - 15-50 mg topiramate.
Auxiliary components: sucrose, starch, povidone, cellulose acetate, gelatin.
Topamax is available in capsules of 15, 25 and 50 mg, placed in a cardboard box for 28-60 pieces.
Pharmacological Effects of Topamax
Topamax is an effective antiepileptic drug that increases the activity of GABA receptors and normalizing effect of AMPA receptors. The preparation is used to treat epilepsy in the initial stage, migraine and spasmodic states of different aetiology.
Topamax has antispasmodic, analgesic and anti-inflammatory effect.
Topamax has received good reviews as a preparation for the rapid elimination of seizures and relieving nervous excitability.
During treatment, patients who drives the vehicle and engaged in activities on hazardous sites, care must be taken. Topamax reduces the speed of psychomotor reactions.
Topamax is indicated for the treatment of epilepsy, tonic-clonic seizures, migraines, Lennox - Gastaut syndrome, absence seizures, myoclonic and partial seizures.
Positive feedback Topamax is a drug as an aid to eliminate muscle spasms of smooth muscle.
Analogs of Topamax
Analogues of Topamax are Maksitopir, Topalepsin, Topsaver, Toreal and Epimaks. These drugs exert similar pharmacological effects, and are effective for the treatment of epilepsy, in both monotherapy and in combined therapy.
Instructions for use of Topamax
In accordance with the instructions, Topamax epileptic seizures when taken orally at 200 mg 2 times a day. If necessary, the contents of the capsule may be mixed with a small amount of water.
Adult patients can take Topamax, together with other anticonvulsants. The correct dosage must be established by the attending physician.
At the initial stage of epilepsy need to start taking Topamax 25 mg a day and gradually increase the dosage. Increasing the dosage depends on the patient's clinical indications.
According to the instructions Topamax should not be prescribed to children under 2 years and from 2 to 10 years the dosage should not exceed 50 mg per day. Patients with kidney disease, the dosage should be minimal.
As an additional antiepileptic
Topamax means you must take 9 mg 2 times a day. The course of treatment lasts for 7 days.
Topamax for migraine take prescribed 100 mg 2 times a day. In severe migraine attacks dosage is increased up to 200 mg two times a day. To prevent the patient should take the drug for 1 week for 1 to 25 mg once a day (at night).
Contraindications to the appointment of Topamax are hypersensitivity and intolerance to the components of the drug, pregnancy, lactation, children under 2 years of age, liver failure, severe brain disease, heart failure, malignant tumors.
With care prescribe medication when nefrourolitiaze, kidney failure, and osteoporosis in the elderly.
Side effects of Topamax
Topamax may cause the following side effects:
- on the part of the digestive system - diarrhea, nausea, vomiting, weight loss, loss of appetite;
- the central nervous system - the confusion, headache, dizziness, drowsiness, fatigue, depression, hallucinations, anxiety;
- From the senses - decreased vision, myopia, redness of the mucous membrane of eyes, mydriasis, increased intraocular pressure;
- allergic reaction - hives, itching, inflammation of mucous membranes, angioedema, dermatitis.