Tinidazole - a drug with antibacterial and antiprotozoal properties.
The composition and the form of tinidazole
Tinidazole is produced in the form of round, biconvex tablets, film-coated white. Each tablet contains the active ingredient - 500 mg tinidazole.
Additional components: purified talc, corn starch, lactose, Opadry white 04V 58909, methyl hydroxybenzoate, magnesium stearate, anhydrous colloidal silica.
The package of four tablets.
Analogues of tinidazole are the following drugs: Tiniba, Pilobakt, Fazizhin, Trikolam, Tridazol, Trinigin, Tinisan, Trikaniks, Torres, Tinogin, Tinimed, Ametin.
According to the instructions Tinidazole is an antiprotozoal drug with antibacterial action. The mechanism of action due to damage to the structure of DNA synthesis and inhibition of pathogens.
The use of tinidazole actively against Lamblia intestinalis, Entamoeba histolytica, Trichomonas vaginalis. Produces a bactericidal effect against anaerobic bacteria following: Veillonella spp., Peptococcus spp., Clostridium spp., Peptostreptococcus spp., Bacteroides spp., Fusobacterium spp., Eubacterium spp ..
Indications for use of tinidazole
According to the instructions Tinidazole is prescribed in the following cases:
- mixed aerobic-anaerobic infection (in conjunction with antibiotic therapy);
- eradication of Helicobacter pylori (in combination with antibiotic drugs and bismuth);
- infections caused by anaerobic bacteria;
- amebiasis (including hepatic form);
In the opinion of Tinidazole is effective in the prevention of postoperative anaerobic infections.
The instructions to tinidazole contain the following contraindications:
- first trimester of pregnancy;
- violations of blood;
- organic diseases of the central nervous system.
Dosing and dosing regimen tinidazole
According to the instructions Tinidazole is for oral administration.
Typically, for adult patients administered the drug or analogue in a dosage of 1 tinidazole, 5-2 g per day for children - 50-75 mg per kg of body weight per day. The duration of treatment is on average from one to ten days.
In the opinion of Tinidazole may cause the following side effects of the various systems of the body:
- pruritus, rash, urticaria, angioedema,
- dizziness, headache, peripheral neuropathy, incoordination, fatigue, dysarthria;
- dryness of mucous membranes of the mouth, diarrhea, vomiting, metallic taste in mouth, anorexia, nausea;
- transient leukopenia.
Weakness and cramps Tinidazole Review is rare.
Drug interaction Tinidazole
With the simultaneous use of the drug or analogue tinidazole ethanol there is the possibility of disulfiramopodobnyh effect.
The use of tinidazole during pregnancy and breastfeeding
In the first trimester of pregnancy is contraindicated Tinidazole. In the second and third trimester should only be prescribed the drug at a ratio of benefits and risks for the mother and the fetus.
Use of the drug during lactation requires cessation of breastfeeding.