Entsevir - a vaccine that reliably protects people from infection with the tick-borne encephalitis. It contains an inactivated whole virus, i.e. virus which as a result of a special treatment has lost the ability to replicate (reproduction) and can not lead to the development of the disease.  Entsevir - a vaccine against tick-borne encephalitis

Pharmacological action

The instructions to Entseviru indicated that the drug stimulates the humoral and cellular immunity against the virus encephalitis. Vaccine Entsevir creates a sufficiently high protection against strains of virus circulating in Europe and Asia.

Indications Entsevira

According to the instructions Entsevir used for the prevention of tick-borne encephalitis. The vaccination need people living and coming to the adverse incidence of tick-borne encephalitis place, especially if they are fully engaged in the construction, agricultural, irrigation and drainage, geological and logging operations. In addition, the need to vaccinate people whose work is connected with the living virus cultures. Vaccine Entsevir also used to immunize the donor to further receive from their plasma specific immunoglobulin.

Contraindications Entseviru

According to the instructions Entsevir contraindicated in the following cases:

  • Individual hypersensitivity to the drug;
  • Severe food allergies, especially to egg protein;
  • Bronchial asthma;
  • If the previous administration of the vaccine followed by the development of complications or the appearance of severe reactions (swelling and redness at the injection site of more than 80 mm in diameter, increase in body temperature above 40 degrees C);
  • Epilepsy;
  • Thyrotoxicosis;
  • Diabetes;
  • Cancer;
  • Blood diseases.

Entsevir vaccine should not be used for immunization of pregnant women. Its administration may not earlier than 14 days after birth. Also, vaccination is not carried out against the background of acute medical illness or exacerbation of chronic. Vaccination can only be carried out one month after recovery or remission.

Side effects Entsevira

Using vaccines Entsevir may be accompanied by:

  • Painful swelling of the soft tissues and hyperemia (redness) at the injection site;
  • A small increase in regional lymph nodes;
  • Increase in body temperature to 38 degrees C;
  • Headache;
  • Malaise;
  • Pain in joints and muscles (arthralgia and myalgia).

The instructions to Entseviru noted that the side effects of this drug can be shown in the first two days after its introduction, and is usually not stored for more than three days.

The vaccine Entsevir rarely leads to the development of immediate allergic reaction (anaphylaxis, angioedema).

Entsevir: instructions for use

The drug is injected into the deltoid muscle. His single dose of One-half. Primary vaccination can be carried out by one of two schemes:  Entsevir - vaccine for intramuscular administration

1. The first vaccination is done in the selected patient day. The second is done in two months, and the third - a year.

2. The first vaccination is done in the selected patient day. The second is done after 5-7 months, and the third - a year.

Revaccination is carried out every three years. This vaccine is administered once Entsevir.


Using a vaccine Entsevir in any case it is impossible to prevent intravascular injection, since This can lead to serious allergic reactions, which require an anti-shock and resuscitation therapy.

After vaccination, patients should remain under the supervision of health care workers about half an hour.

In carrying out vaccination in the spring-summer period, ie when there is high activity of ticks, you should exclude the possibility of contact with the graft source of infection for the duration of the vaccination and two weeks after its completion.

Before the vaccination grafting must necessarily be examined by a doctor or nurse to detect possible contraindications. This necessarily going to a thorough medical history and measured body temperature. The physician is personally responsible for the validity of the appointment of the vaccine Entsevir.

Vaccination should only be performed in the treatment room by specially trained medical personnel. The office must necessarily be laying for quickly and fully to provide assistance in the event of a graft of his allergic reaction.

Dosage form

Entsevir vaccine produced in a slurry intended for intramuscular administration.