Tazepam - antianxiety drug for the treatment of neuroses.
Pharmacological action tazepama
Tazepam belong to the group of synthetic benzodiazepine tranquilizers. They have a calming effect and are used to eliminate anxiety symptoms psychotic nature. The exact steps tazepama can be characterized as anxiolytic (antinevroticheskoe) - it eliminates fear and general anxiety, almost causing drowsiness. With this drug has gained the status of "daily tranquilizer"
The main active ingredient of tazepama instructions - oxazepam. The pharmacological action is carried out by reacting it with benzodiazepine receptors that are closely related to GABA receptors in the brain. GABA (gamma-aminobutyric acid) in the nerve synapse acts as a brake material. Excitation benzodiazepine receptors in conjunction with their oxazepam automatically turned on GABA receptors in the nerve synapse accumulates brake neurotransmitter GABA, allowing enhanced braking processes at all levels of the central nervous system, but especially in the subcortical brain responsible for the emotional state (limbic system, reticular formation, etc.).
Since tazepam able to act on the different structures in the brain, it therefore has diverse effect - sedative, muscle relaxant (muscle relaxant), anticonvulsant, anxiolytic (reduces emotional stress).
Sedation is expressed in the application tazepama slightly, and is associated with inhibition in the reticular formation of the brain stem. As a result of inhibition decreases the impact of emotional, autonomic and motor stimuli that can disturb the sleep mechanism.
Muscle relaxation is achieved by inhibiting spinal reflexes (central inhibition), and to some extent the direct effect on the motor nerve trunks and muscle function.
Tazepam virtually no effect on productive symptoms of psychotic disorders (delusions, hallucinations).
When using tazepama inside it absorbed more slowly with respect to its peers, but quickly formed in the liver to active metabolites, which have even more anxiolytic effect than the tazepam. Therefore, the maximum effect occurs immediately after reception, and a short time later.
Tazepam excreted from the body and its metabolites in the urine.
The drug is available in tablets of 10 mg.
According to the instructions tazepam used for nervousness and states with autonomic disorders, sleep disorders, irritability. These symptoms may be accompanied by physical illness. In the opinion of tazepam well it helps in treatment of reactive depression, withdrawal syndrome and autonomic failure.
Do not use the drug in case of hypersensitivity to the tazepam him with severe depression, narcotic poisoning, chronic obstructive pulmonary disease in a severe in 1 trimester of pregnancy (teratogenic effects on the fetus) and during lactation, children under 6 years old, with myasthenia gravis, closure glaucoma. With drug use extreme caution in patients with renal and hepatic insufficiency, the propensity to abuse drugs, in the elderly and children aged 6 to 12 years, with organic diseases of the central nervous system, sleep apnea.
Instructions for use tazepama
The drug is intended for oral use, its effectiveness does not depend on food intake. The treatment by the physician, the average duration - 2 - 4 weeks, with tapering at the end to avoid withdrawal. During treatment, prohibited alcohol intake.
Starting tazepama dose is 5 - 10 mg to receive 2 - 3 times a day, it is gradually brought to 30 - 50 mg / day. In heavy conditions the maximum dose to 120 mg / day, but only in-patient treatment. At these doses, it is important to control the risk of drug dependence as soon as possible by reducing the dose. For older people, the dose should be reduced. In the opinion of tazepam with constant use not long before his birth can cause physical dependence and withdrawal symptoms in the infant.
Tazepam better tolerated in comparison with other tranquilizers. Yet during treatment, it can cause many unpleasant symptoms - drowsiness, headache, unsteadiness of attention, nausea, vomiting, constipation or diarrhea, kidney malfunctions, dysmenorrhea, myasthenia gravis, dysarthria, as well as violations in general and biochemical blood tests.