Tayled - antiallergic drug for the treatment of reversible airway obstruction.
Pharmacological action Tayleda
Tayled - inhaled drugs from the group of stabilizers of membranes of mast cells. It is based on nedocromil sodium.
Spreading during inhalation of the bronchi of different sizes, the drug stabilizes the membranes of mast cells, eosinophils, alveolar macrophages. As a result of them blocking the release of biologically active substances that can cause the immune and inflammatory response in the bronchi. It histamine, leukotrienes and other active cytokines provoke bronchospasm and obstruction. Release of them in bronchial hyperreactivity may cause both immune (allergens) and preimmune factors, for example, cold or polluted air, vapor inhalation of irritants.
Tayled anti-inflammatory and anti-allergic effect, not having antihistamine properties, and dilates the bronchi. As anti-inflammatory activity Tayled 4 - 10 times higher than its counterpart Intal. The therapeutic effect of the drug begins to have just a week from the beginning of the course, so it does not apply to emergency medications at airflow obstruction. The drug eliminates bronchial hyperreactivity, improved respiratory function, prolongs remission and reduces the frequency and force of attacks of breathlessness and cough in bronchial asthma and allergic cough.
In clinical practice, you get good reviews about Taylede the treatment of infectious-dependent asthma. He vysokobezopasen unlike other funds for the basic treatment of asthma.
The positive aspects of application Tayleda not directly related to its main mechanism of action is the reduction of the permeability of the blood vessels of the bronchial mucosa, which eliminates the edematous component of bronchial obstruction.
The drug acts locally, on the walls of the bronchi settles Tayleda to 10%, about 5% in the bronchial mucosa is absorbed into the bloodstream and binds to plasma proteins, the rest falls into the digestive tract, but sucked out a little (about 2%). Excretion of unchanged happens with urine and feces.
Tayled discharged in aerosol dosage form, the cylinder contained 112 doses, each 2 mg nedocromil sodium.
According to the instructions Tayled used as part of the basic treatment of asthma different genesis mild to moderate severity, bronchospastic responses to physical exertion, cold air, etc. The drug is also effective in allergic bronchitis.
Tayled can not be used in case of hypersensitivity to the drug in 1 trimester of pregnancy and in children under two years of age.
Instructions for use Tayleda
The starting dose for adults and children 2 years of 2 inhalations (4 mg) for 2 to 4 times a day, depending on the response of the patient to the therapeutic dose. The disappearance of the "morning dips' forced expiratory volume (FEV) for 1 second is one of the criteria for effective therapy chosen. Duration of treatment may be from 4 to 6 weeks of continuous administration. The maximum permitted daily dose - 8 inhalations.
Before use, you need to carefully shake the spray of medicine and take it straight, putting his thumb on the base. After the maximum possible exhalation should tightly embrace mouthpiece lips, then start simultaneously and breath spray one or two doses. After inhalation need to remove the mouthpiece from the mouth and hold your breath as much as possible.
Tayled reduces the need for bronchodilators and allows you to reduce the dose of glucocorticoids in the basic therapy while receiving it.
Side effects Tayleda
In the opinion of Tayled well tolerated, even with prolonged administration. Occasionally there are mild symptoms as a feeling of bitterness and a dry mouth, nausea, headache, cough, or hoarseness.