Taxotere - a cytostatic agent for the treatment of tumors.
Taxotere refers to a group of anticancer drugs - taxoids. The main active ingredient in it - docetaxel. It is produced by chemical synthesis of natural products of biomass - evergreen yew needles. It is known that tumor cells lose control and begin to share non-stop. The mechanism of action of Taxotere based on the fact that it gives them the process of mitosis, tubulin into microtubules accumulating nucleus, which prevents the breakdown of microtubules and consequently cell division. Furthermore, Taxotere detrimental effect on certain types of cells producing the glycoprotein variant which is encoded by a gene of resistance to multiple chemotherapeutic agents.
Effect of the drug proved to breast cancer cells, lung, prostate, stomach, ovaries.
Taxotere is compatible with all other means of standard chemotherapy regimens, it is used in the treatment of adult humans. Well studied the pharmacokinetics. Excreted from the body in preparation for 2 days mostly as metabolites in the feces, and quite a bit - unchanged.
Taxotere is produced in glass vials in a concentrate for solution for infusion of 20 mg (0, 5 mL), 80 mg (2 mL) or 160 mg (8 mL) in a flask of the docetaxel. Comes solvent - 13% ethanol in water for injections.
According to the instructions Taxotere is used in the treatment of operable breast cancer with a lesion of regional lymph nodes or without metastatic or locally advanced breast cancer. An effective treatment of lung cancer in the absence of the effect of therapy or if it is impossible to hold it resection (removal). Also Taxotere Review good for the hormone-refractory prostate cancer and metastatic ovarian cancer when first-line treatment was ineffective. The drug can be used in first-line therapy for metastatic gastric cancer and the transition zone stomach into the esophagus.
Taxotere under the instruction can not be used at low levels of neutrophils in the blood (less than 1500 / mm) in the case of hypersensitivity to the drug, pregnancy, lactation and children under 18 years of age, in violation of the liver. Starting treatment Taxotere, you need to carefully examine the possible contra combination with other drugs. It is important to be careful in using it in conjunction with cyclosporine, terfenadine, erythromycin group and imidazole antifungal agents.
Instructions for use of Taxotere
Taxotere is intended only for treatment in a hospital with oncologist with experience chemotherapy. All patients prior to use as premedication give steroids inside - they help prevent hypersensitivity reactions and reduce fluid retention. The drug is administered intravenously 1 hour once every three weeks.
The dose of Taxotere, as well as other anti-tumor agents, calculated on a body surface area. It is 75 - 100 mg per square meter of surface, depending on the drug, which is in combination. As monoterapiiTaksoter instructions recommended for the treatment of metastatic ovarian cancer (100 mg / m2 every 3 weeks). During the course of chemotherapy should monitor the level of neutrophils in the blood and reduce them to 500 / l, and in severe peripheral neuropathy following dose administration is reduced by 15 - 25 mg / m2.
The vial prior to use be kept at room temperature for 5 minutes. Under the conditions of asepsis of the vial is removed and the desired amount of solution injected into the vial with 5% glucose, or 0 9% sodium chloride. The contents of the vial after joining the two solutions mix by gently inverting the vial to avoid foaming. Ready solution is fit for no longer than 6 hours of preparation.
Side effects of Taxotere
In the opinion of Taxotere gives a lot of side effects of varying severity. They include neutropenia, anemia and thrombocytopenia, and allergic skin reactions, dyspnea, alopecia, nausea, vomiting, diarrhea and constipation, stomatitis, esophagitis, muscle weakness and fatigue, neurosensory reaction, muscle and joint pain.
Other side effects reported and with a combination of chemotherapy drugs. For example, the combination with Taxotere and cisplatin compared with Taxotere monotherapy, frequently gives complications as thrombocytopenia and severe anemia, as well as nausea, diarrhea and anorexia.