Tamoxifen refers to a group of antitumor agents, and nonsteroidal antiestrogen action. The drug stops the development of tumors, reduces inflammation and stimulates the release of pituitary hormones.
Structure and Composition
The main active ingredient - 20-40 mg tamoxifen citrate.
Auxiliary components: sodium starch, povidone, cellulose, magnesium stearate, lactose.
Tamoxifen is available in tablets of 10, 20 and 40 mg coated yellow. The shell of each tablet consists of titanium dioxide, lactose, polyethylene glycol, hypromellose.
The pharmacological properties of Tamoxifen
Tamoxifen is an anticancer drug that stops the hypertrophy of cells, suppresses the synthesis of tumor tissue and inhibits the formation of tumors.
Tamoxifen has good reviews as an effective drug for the prevention of tumors.
The drug with the first dose blocks the action of estrogen for several weeks. Tamoxifen does not cause side effects associated with the increase in cell and tissue overgrowth. The drug is quickly absorbed and starts to be active for 30 minutes.
In men with impaired ejaculation Tamoxifen can cause an increase in the concentration of testosterone and estrogen in the blood.
After the first receiving Tamoxifen reaches maximum concentration in the blood for 5-7 hours. The drug is metabolized in the liver to form several metabolites benign. Tamoxifen is output from the body within 15 hours.
Indications for use of Tamoxifen
Tamoxifen is prescribed for the treatment of the following cancers:
- breast cancer and breast;
- ovarian cancer, prostate cancer;
- endometrial cancer;
- kidney cancer;
Positive feedback received Tamoxifen as a drug for the treatment of tumors of different etiology and uzlovidnyh formations in the soft tissues.
Instructions for use of Tamoxifen
According to the instructions Tamoxifen should be administered after the diagnostic studies that include: gynecological diagnosis, a blood test, the definition of indicators of the level of cholesterol and hemoglobin examinations of liver and kidney functioning, examination by an ophthalmologist and determining blood pressure.
Tamoxifen begins with 20 mg 2 times a day, and then increasing the dosage to 40 mg 2-3 times a day. The course of treatment lasts from 30 days to 3 months. Treatment is carried out in combination with radiation therapy and drugs, inhibiting the process of cell division.
In accordance with the instructions Tamoxifen must be taken orally, washed down with copious amounts of vody.Sutochnaya dose should be divided into two equal reception - morning and evening.
The drug can cause unscheduled ovulation, so the period of treatment prescribed reliable birth control pills.
During treatment, patients driving or working in hazardous objects should be careful. Tamoxifen inhibits the motor response and dulls attention.
Contraindications to tamoxifen are hypersensitivity and intolerance to the components of the drug, pregnancy and breastfeeding, leukopenia, cataract, thrombosis, renal and hepatic failure, cardiovascular diseases at advanced stages of the flow.
Precautions drug indicated for thrombocytopenia, thrombocytosis, hypercalcemia, diseases of the brain.
Side Effects of Tamoxifen
Tamoxifen may cause the following side effects:
- on the part of the digestive system - nausea, diarrhea, vomiting, indigestion, loss of appetite, cholestasis, liver infiltration, increase in body weight;
- on the part of the circulatory system - thrombosis, thrombocytopenia, leukopenia;
- the central nervous system - headache, confusion, fainting, dizziness, drowsiness;
- on the part of the genitourinary system - cystic tumors, uterine bleeding, painful vaginal discharge, itching and burning genitals, reduced potency.
In some cases, Tamoxifen can cause side effects allergic - fever, skin rash, urticaria, bronchospasm, flushing of the skin, dermatitis, alopecia.