Mifepreks - a synthetic steroid antigestagens drug.

Structure and Composition

Mifepreks release tablets. One tablet contains the active component - mifepristone 200 mg.  Mifepreks Tablets should be used under strict medical supervision

Pharmacological action

According to the instructions Mifepreks blocks the action of progesterone at gestagenovyh receptors. There is antagonism with corticosteroids does not have progestin activity.

In the opinion of Mifepreks increases contractility of the myometrium, increases its sensitivity to prostaglandins and stimulates the release of interleukin-8 in horiodetsidualnyh cells. To enhance the effect of the drug it is often prescribed in combination with a synthetic analogue of prostaglandin. Effect of the drug leads to desquamation decidua and removal of the ovum. Use of the drug inhibits ovulation, promotes endometrial changes, resulting in the implantation of a fertilized egg can not be realized.

Moreover, the drug promotes progesterone receptor blockade, which helps stop the growth of the tumor, as well as reduce the size and uterine fibroids.

Indications Mifepreksa

According to the instructions Mifepreks prescribed for medical termination of pregnancy at a very early period (up to 42 days of amenorrhea).

Also, the drug is prescribed for emergency contraception immediately (no more than 72 hours) after unprotected intercourse, as well as when there are doubts that the previously selected method of contraception unreliable. Shows a drug for the treatment of uterine fibroids, the size of which reaches 12 weeks of pregnancy, and for the training and induction of labor at term.

Dosing and dosing regimen Mifepreksa

Mifepreks allowed to be used only in specialized institutions, where there is all the necessary equipment.

In order for medical termination of pregnancy Mifepreks tablet administered once at a dose of 600 mg, or three tablets. The patient takes the drug inside only in the presence of the attending physician. Admission should be carried out after 1-1, 5:00 after the meal. The tablets washed down with half a glass of water. Within two hours after taking the drug the patient should be under constant medical supervision. After 1, 5-2 days after administration of the drug the patient should come to the hospital for examination and to undergo ultrasound. If necessary, the patient may be given misoprostol.

Two weeks later, the patient must again undergo ultrasound and, if necessary, to be tested to determine the level of human chorionic gonadotropin to confirm the miscarriage.

If the drug did not have the desired effect for two weeks (incomplete abortion or ongoing pregnancy), the patient is carried out vacuum aspiration and histological examination of the aspirate.

In the case of full-term pregnancy Mifepreks may designate for the induction of labor. The dosage of the drug in this case is 200 mg per day (one tablet). The drug is carried out in the presence of a physician. After a day may be reappointed reception at the same dosage, but after 2-3 days it is necessary to assess the state of the birth canal. If necessary, the patient subsequently administered oxytocin or prostaglandins.

Contraindications Mifepreksa

According to the instructions Mifepreks has quite a list of general contraindications, namely:

  • acute or chronic renal or hepatic impairment;
  • prolonged use of corticosteroids;
  • uterine fibroids;
  • adrenal insufficiency;
  • age over 35 years old and smoking;
  • inflammation of the female genital organs;
  • porphyria;
  • Hypersensitivity to the active or auxiliary components of the drug;
  • severe anemia;
  • the presence of a complex of extragenital pathology;
  • hemostatic disorders, including due to anticoagulation therapy.

If tablets Mifepreks prescribed for medical termination of pregnancy, they are contraindicated in the following cases:

  • pregnancy, duration of which more than 42 days after the lack of menstruation;
  • unconfirmed pregnancy;
  • ectopic pregnancy or suspicion of it;
  • pregnancy, emerged during the application of intrauterine contraception or immediately after the cancellation of hormonal contraceptives.

In preparation and induction of labor Mifepreks contraindicated in the following cases:

  • severe preeclampsia;
  • eclampsia;
  • malposition;
  • preeclampsia;
  • Prolonged or preterm pregnancy;
  • bleeding from the vagina during pregnancy of unknown origin;
  • size mismatch of the fetal head and the mother's pelvis.

In the opinion of Mifepreks should be used with caution in patients with bronchial asthma, obstructive lung disease, arrhythmia, hypertension, chronic heart failure.

Side effects Mifepreksa

In the opinion of Mifepreks can cause malaise, discomfort in the abdomen, vomiting, nausea, headache, hypothermia, dizziness, subinvolution uterus lohiometru.

In the case of the procedure, medical abortion may be bleeding from the genital tract, exacerbation of inflammatory processes in the uterus and appendages, abdominal pain.

Application Mifepreksa during pregnancy and breastfeeding

After receiving Mifepreksa not recommended to breast-feed the baby for three days.

Tablets Mifepreks when used to prepare for childbirth do not have a negative impact on the subsequent lactation.


In case of overdose Mifepreks, reviews, can cause adrenal insufficiency.  Mifepreks is narrowly targeted drug

Interaction Mifepreksa with other drugs

The drug reduces the effect of corticosteroids, so their simultaneous application is recommended to increase the dosage of corticosteroids.

You can not combine the reception Mifepreksa with NSAIDs.


Patients who use the drug for medical termination of pregnancy should be aware that if within two weeks the drug does not have the desired effect and the pregnancy continues, you must terminate it in another way, as there is a risk of formation of congenital malformations in the fetus.

Storage conditions

Mifepreks refers to drugs list A with a recommended shelf life of no longer than 3 years.