Equator - a drug that reduces blood pressure.
The pharmacological properties of the Equator
According to the instructions Equator is a combined tool, it contains amlodipine and lisinopril.
Lisinopril is an ACE inhibitor. Its mechanism of action involves blocking the conversion of angiotensin II from angiotensin I in the renal tissue. This reduces the effect of aldosterone on water metabolism, increases the formation of prostaglandins.
Lisinopril lowers blood pressure by expanding blood vessels (arteries dilate more than the veins) and reduce the total peripheral vascular resistance (SVR). Furthermore, its effect on the heart is reflected in the fact that:
- Reduced preload;
- Reduces the pressure in the pulmonary capillaries;
- Increases resistance to stress of the heart muscle;
- Increases minute volume of blood flow.
Regular long-term use of pills Equator improves blood flow to the heart and reduces its hypertrophy. It is proved that products from a number of ACE inhibitors prolong life in the presence of congestive heart failure, slow the progression of left ventricular dysfunction after myocardial infarction.
More Actions lisinopril is the reduction of albuminuria, which allows him to recommend a combination of hypertension with diabetic nephropathy, but glucose levels are not affected at all.
Amlodipine - a second constituent component of the Equator. It is the active ingredient from the group of calcium channel blockers slow. Amlodipine reduces passage of calcium ions into smooth muscle cells. Its effect on the cardiovascular system can be described as anti-anginal and antihypertensive. The principle of action of amlodipine tablets Equator similar lizinoprilu - reduced total peripheral vascular resistance and improves blood flow to the myocardium.
The combination of two active agents in a single formulation and one complementary eliminates undesired side effects. Thus, calcium channel blockers typically retained in the body of sodium and water, and ACE inhibitors, conversely, inhibit this process.
Action Equator under the instruction begins at 1 hour, the maximum effect is seen after 6 hours after ingestion. The therapeutic effect of the Equator, in the opinion, maintained throughout the day.
When high blood pressure, a positive effect on the Equator instructions appears in the early days of its application for long-term permanent effect it is necessary to take the drug continuously.
Displayed Equator unchanged in metabolites in the body, he does not turn.
Equator release tablets of 5 and 10 mg (of amlodipine).
The drug is prescribed, if necessary, a combination therapy for high blood pressure.
You can not apply the Equator and its intolerance of other ACE inhibitors, stenosis (narrowing of the outlet) aortic and mitral valve in case of hemodynamic significance.
Contraindications to the Equator will receive tablets hereditary and idiopathic angioedema, hypertrophic cardiomyopathy with obstruction, marked reduction in blood pressure (systolic blood pressure below 90 mm. Hg. V.), Heart failure after myocardial infarction, unstable angina, cardiogenic shock, pregnancy and breastfeeding . Children under 18 years receive instruction on the Equator is not recommended.
Caution is required in the application of the Equator in bilateral renal artery stenosis, primary hyperaldosteronism, renal and hepatic dysfunction after kidney transplantation, with hyperkalemia.
Instructions for use of the Equator
The drug should be taken one time a day, in the morning, drinking water, without reference to the food intake. In the initial period the patient may be concerned about pressure reduction in patients receiving diuretics before, so the diuretic before starting treatment Equator canceled up to 2 - 3 days.
If the use of diuretics is necessary, the dose is reduced to 0 Equator, 5 tablets. During the course of therapy is required periodically to monitor kidney function, blood potassium and sodium in the blood.
Side effects of the Equator
According to reviews, the Equator can sometimes give such adverse reactions as headache, dizziness, or cough. They are their own and do not require discontinuation of therapy.