Sydnopharm - pharmacological agents from the group of vasodilator used to prevent strokes.
Structure and Composition
According Sydnopharm instructions issued in the form of 2 mg tablets. The active ingredient - molsidomin. Also includes auxiliary components: wheat starch, lactose, colloidal silicon dioxide, magnesium stearate, hydroxypropyl methylcellulose, peppermint oil, microcrystalline cellulose.
Externally Sydnopharm a round tablets light pink color, convex on both sides, with a pleasant mint aroma. Produced the drug in blister packs of 10 tablets. The carton 3 blisters with instruction.
Pharmacological action Sydnopharm
According to the instructions Sydnopharm has vazodilyatiruyuschim (vasodilator) effects. The drug has antianginal, antiplatelet, venodilatiruyuschee and analgesic effect. As a result of metabolites occurs Sydnopharm relaxation of smooth muscle fibers of the vessel wall (mainly veins), thereby reducing the preload on the heart. The drug also extends the narrowed portion of the coronary arteries and improve blood flow to collateral attack. Application Sydnopharm increases exercise capacity, reduces the frequency of angina attacks (which occur during exercise).
According to the instructions Sydnopharm prevent early platelet aggregation, reduces the release of serotonin, thromboxane and other proagregantov.
Action Sydnopharm starts about 20 minutes after ingestion and reaches its maximum after 1 hour. The duration of action of the drug for about 6 hours. Prolonged use Sydnopharm causes development of tolerance with a decrease in the efficiency of the preparation (in contrast to the nitrate).
Withdrawal of the drug in the kidneys (90%). The half-life of about 2-2, 5:00.
Sydnopharm with prolonged use are not cumulated in the body, even in patients with renal insufficiency.
According to the instructions Sydnopharm recommended for the prevention of strokes.
- hypersensitivity to the ingredients of the drug;
- hypotension (systolic blood pressure if lower than 100 mm Hg);
- collapse, cardiogenic shock, acute myocardial infarction (arterial hypotension);
- age 18 years;
- pregnancy and lactation.
Precautions Sydnopharm need to use in patients with a history of hemorrhagic stroke, increased intracranial pressure, a tendency to arterial hypotension, glaucoma (especially the closure).
Instructions Sydnopharm: Dosage and administration
According to the instructions Sydnopharm taken orally, swallowing whole with plenty of water, regardless of meals.
Usually beginning with low doses of 1 - 2 mg twice a day. If necessary multiplicity of purposes may be increased to three times per day. Sydnopharm maximum dose is 6 mg per day.
The duration of treatment and dosage of the drug individually selected by the attending physician. In the opinion of Sydnopharm well tolerated and effectively prevents the development of angina attacks.
Side effects Sydnopharm
According to reviews Sydnopharm rarely causes side effects. Among them are most common are: headache (which disappears continued administration of the drug), dizziness, low blood pressure, redness of the skin, nausea, loss of appetite. In patients with initially low blood pressure may develop collapse. Rarely when receiving Sydnopharm, reviews, experience an allergic reaction (skin rash, urticaria, bronchospasm, anaphylactic shock), slowing of motor and mental reactions (usually at the beginning of treatment), diarrhea.
Symptoms of overdose Sydnopharm are severe headaches, tachycardia, low blood pressure expressed. Treatment - symptomatic. No specific antidote.
Interaction Sydnopharm with other drugs
When concomitantly with other antihypertensive and vasodilator agents, as well as with ethanol increased antihypertensive effect.
Application Sydnopharm simultaneously with drugs acetylsalicylic acid increases the antiplatelet activity.
According to the instructions Sydnopharm can not be used for the relief of angina attacks.
The first dose of the drug is prescribed with caution and under the control of blood pressure due to the possible occurrence of headaches and excessive reduction of blood pressure.
Patients elderly and patients with impaired hepatic / renal dose adjustment is needed Sydnopharm.
Since the drug can vary the speed of motor and psychological reactions, the period of treatment (especially at the beginning) should give up driving and working with moving machinery.
Sydnopharm analogues are dilasidom, korvamin, korvaton, molsidomine. Before replacing analogue Sydnopharm should consult a doctor.