Sulgin - antibacterial drug, a derivative of the substance sulfanilamide.
The active ingredient of the drug - sulfaguanidine.
Form release - white pills. The composition of one tablet contains: sulfaguanidine (0, 5 g) and adjuvants (primdgel, calcium stearate, potato starch).
Pharmacological action sulgin
According to the instructions sulgin, the drug is effective against gram-negative, gram-positive bacteria and pathogens of intestinal infections. The mechanism of action is due to inhibition of sulfaguanidine digidropteroatsintetazy that leads to disruption of the formation of tetrahydrofolic acid, which is necessary for the synthesis of pyrimidine and purine.
Sulgin feature is the slow absorption of active substances from the gastrointestinal tract, whereby the drug is retained in the body, providing a high concentration in the intestine sulfaguanidine. In the opinion of Sulgin an effective drug for the treatment of intestinal infections, similar in action with ftalazolom.
The drug is indicated for the acute, subacute and chronic bacillary (bacterial), dysentery, enterocolitis, colitis (diarrhea), carriers of typhoid sticks, as well as in preparation for surgical operations on the large and small intestine.
Sulgin not recommended in the presence of hypersensitivity to the drug, hyperbilirubinemia, nefrourolitiaze, lack of glucose-6-phosphate dehydrogenase, B12 deficiency anemia. According to the instructions Sulgin prohibited to use pregnant women, nursing mothers and children in infancy.
Side effects sulgin
Active substance sulgin may fall in the urinary tract in the form of crystals sulfaguanidine. The feedback to the sulgin said that to avoid this side effect during treatment, you can use the enhanced diuresis. It is recommended to drink at least 2-3 liters of fluid per day.
Moreover, the application could cause sulgin hypovitaminosis associated with inhibition of the synthesis of B vitamins (riboflavin, thiamine, nicotinic acid) because of the suppression of E. coli involved in the synthesis of these substances. Also, as a side effect, according to the reviews sulgin, marked vomiting, nausea, and skin rash.
Interaction with other drugs
According to the instructions to sulgin medicine reduces the effectiveness of oral contraceptives. Procaine, benzocaine, procaine, benzocaine reduces the antimicrobial activity of the drug. These antidiabetic drugs like coumarin anticoagulants, phenytoin increase the likelihood of side effects of the drug, and the combined use of sulgin with ascorbic acid and hexamethylenetetramine increases the acidity of urine, contributing to the emergence of crystalluria.
Dosing and dosing sulgin
According to the reviews sulgin, the course of treatment of acute intestinal infections continues 5-7 days, accompanied by dosage 2-4 tablets 3-4 times a day, unless prescribed by a doctor.
In order to prevent complications Sulgin recommended for use at a dose of 0, 05 g / kg body weight every 8 hours for 5 days before surgery and for a week after surgery.
The maximum single dose of the drug (for adults) is 2 g daily - 7 g
Storage preparation is carried out of the reach of children, dry place at temperatures no higher than 25 degrees Celsius.
Instruction sulgin presented for informational purposes only. Before using the drug, consult a physician.