Sulfalen - synthetic antimicrobial broad-spectrum drugs.
Active ingredient sulfalena has antibacterial action against Gram-positive and Gram-negative cocci, as well as against Actinomyces spp., Chlamydia spp., Plasmodium and Toxoplasma gondii.
Bacteriostatic effect, has an active substance sulfalena, is more lasting than many other antibiotic drugs.
The mechanism of action due to a violation of the synthesis of dihydrofolic acid, which is involved in the synthesis of pyrimidine and purine.
Form release sulfalena
Sulfalen produced in the form of tablets of 200 mg.
As a solution for intravenous and intramuscular administration, releasing the drug Sulfalen Meglumin. In 5 ml ampoules containing 0, 5 g of the active substance.
Analogues sulfalena mechanism of action drugs are Sulfadimetoksin and Sulfapiridazin.
According to the instructions inside the prepara indicated for the treatment of infectious diseases that cause sensitive to the action of microorganisms sulfalena, namely:
- Purulent infections of different localization - abscesses, wound infections, mastitis;
- Infections of the respiratory system - bronchitis, pneumonia;
- Urinary tract infection - cystitis, pielita, urethritis;
- Biliary tract diseases - cholangitis, cholecystitis.
Sulfalen also used in the treatment of osteomyelitis, otitis, sinusitis, and toxoplasmosis.
In addition, Sulfalen effective in combination therapy to treat malaria (especially in forms exhibiting resistance to monotherapy).
Intravenous sulfalena indicated for the prevention of complications of bacterial infection in the postoperative period and at various forms of purulent infection in urological, neurosurgical, surgical and gynecological practice. The drug is also prescribed for the inefficiency of other chemotherapeutic agents in cases of pneumonia, purulent meningitis and severe sepsis.
The drug is contraindicated Sulfalen apply at:
- Chronic renal failure;
- Suppression of bone marrow hematopoiesis;
- Congenital deficiency of glucose-6-phosphate dehydrogenase;
When kidney disease who are not accompanied by impaired excretory functions Sulfalen usually prescribed with caution.
Sulfalen rather slowly excreted, therefore exceeding the assigned dose could lead to its accumulation in the body.
Dosage and duration of sulfalena and analogues according to the instructions depends on the severity of the disease.
Thus, when acute diseases occurring in the first day of treatment prescribed sulfalena 1g once a day, and then for 7-10 days take 200 mg per day.
To carry out long-term prevention, and the treatment of chronic and recurrent infections, wearing protracted, Sulfalen of instructions is taken once a week for 2 years
Typically, such treatment is administered in diseases of the kidneys and urinary tract, as well as in the treatment of rheumatism and chronic lung disease. As a rule, the treatment in these cases long - up to six months.
For maximum effect Sulfalen be taken no earlier than half an hour before meals.
In some cases, parenteral administration shows sulfalena: intravenous (bolus or infusion) or intramuscularly. Typically, the drug is administered once a day.
On the first day, the standard dosage is 5 ml, and severe forms of the disease - 10 ml. In the next 7-10 days Sulfalen administered 200 mg.
Sulfalen and analogues are not effective in the treatment of dysentery.
When using sulfalena can develop:
- Dyspepsia, including nausea and vomiting;
- Allergic reactions.
The development of leukopenia, agranulocytosis and other undesirable actions hematopoietic system promotes the simultaneous use sulfalena thioacetazone, nonsteroidal anti-inflammatory drugs and chloramphenicol.
Undesirable side effects associated with the drug gematotoksichnosti reinforce myelotoxicity drugs.
Drug interaction sulfalena
Sulfalen while the use of lincomycin, erythromycin, fuzidinu, novobiocin, levorin tetracyclines and reinforce anti-bacterial action.
Antagonism is observed when combined with:
- Streptomycin and other aminoglycosides;
- Nalidixic acid.
Concomitant use with oxacillin sulfalena may lead to increased toxicity.
The antibacterial activity of the drug inhibit benzocaine, procaine, and tetracaine.
Also note that the use of sulfalena reduces the reliability of oral contraceptives.
Sulfalen refers to the number of antibiotic drugs List B, holidays are available from pharmacies by prescription. Shelf life of the tablets should not exceed four years, the solution - not more than two years.