Fluoroquinolone antibacterial drug.  Sparflo tablets

Structure and Composition Sparflo

Sparflo produced in the form of coated tablets.

One tablet contains 200 mg of sparfloxacin. Other ingredients: magnesium stearate, microcrystalline cellulose, corn starch, talc, crospovidone, colloidal silicon dioxide. The shell consists of titanium dioxide, hypromellose, talc, propylene glycol, quinoline yellow dye.

Pharmacological action Sparflo

Sparflo - bactericidal antimicrobial agent with broad spectrum of action belongs to the group of fluoroquinolones. It inhibits DNA gyrase microorganisms, prevents replication of bacterial DNA. Has a bactericidal effect on gram-positive organisms during fission, and also on Gram - during dividing and quiescent period.

Sparflo blocks transcription of the genetic material of bacteria, without which they can not be normal metabolism, resulting in a rapid decrease in the ability of bacteria to divide. When using the drug were found Sparflo development of cross-resistance to other antibiotics, not belonging to the group of inhibitors of DNA gyrase. This quality makes Sparflo highly active against bacteria resistant to penicillins, aminoglycosides, tetracyclines, cephalosporins.

Unlike analogue has Sparflo postantimikrobnym effect - bacteria do not multiply within 0.5 - 4 hours of complete release of the drug from the plasma.

Pharmacokinetics Sparflo

After receiving the internal Sparflo absorbed about 90%. At a dose of 400 mg, the maximum plasma concentration occurs within 3-6 hours, the drug concentration in tissues at 2-12 times higher than in plasma. The concentration in serum is linearly dependent on the size of the dose

Adoption Sparflo with food or milk does not affect the extent of absorption, but slows down its speed and the maximum concentration in the blood comes about half an hour later.

Sparflo well distributed throughout the body tissues except fat-rich tissues and nerve tissues. The high degree of concentration is detected in alveolar macrophages.

Sparfloxacin is metabolized in the liver and excreted in the feces about 40%. The half-life of 16-30 hours.

In patients with renal insufficiency observed increase in half-life. Also defined percentage reduction in output by the kidneys, the presence of chronic renal failure.


The drug is indicated for Sparflo infectious and inflammatory diseases caused by microorganisms sensitive to the drug.

  • infections of the respiratory tract and lungs;
  • infection of upper respiratory tract;
  • eye infections;
  • urinary tract infections and kidney;
  • genital infections;
  • infection of the abdominal cavity;
  • infections of the gastrointestinal tract;
  • skin infections;
  • infections of joints and bones;
  • tuberculosis;
  • leprosy.


The drug is contraindicated in:

  • epilepsy;
  • arrhythmia with extended interval QT;
  • severe renal failure;
  • pregnancy and lactation;
  • for children and adolescents under 18 years of age;
  • hypersensitivity to the drug.

Sparflo Dosage and instructions for use

The duration of therapy depends on the severity of the disease, the clinical picture and the results of bacteriological examination.

In chronic bronchitis, or pneumonia in the acute stage the drug is taken by the following scheme - on the first day to 400 mg Sparflo single dose, in the next 10 days at 200 mg per day. When sinusitis and other infections of upper respiratory tract, a similar scheme.

In tuberculosis Sparflo appointed in the complex therapy, 1 day assigned 400 mg once-daily in the following days, 200 mg a day, the course - 30 days.

If urinary tract infection in one day take 200 mg one-time, followed by 100 mg per day, the course of 10-14 days

When gonorrheal urethritis acute form day 1 400 mg razovo, then every 24 hours - 200 mg. The dose for the course - 600 mg.

When nongonococcal urethritis in Day 1 200 mg razovo further 100 mg every day for 6 days.

When chlamydial infections and bacterial prostatitis at 1st day 400 mg, then 200 mg per day. The course - 10-14 days.

For infections of skin and soft tissue infections in one-day 400 mg, then 200 mg per day. The course of 3-9 days.

Tablets should be swallowed without crunching or chewing, with liquid.

Overdose Sparflo

In case of overdose symptomatic therapy is recommended, general indications prescribed peritoneal dialysis and hemodialysis. No antidote.

Drug interaction Sparflo

According to reviews Sparflo combined with non-steroidal anti-inflammatory drugs increases the risk of seizures. Please note that Sparflo prolong the QT interval and not to appoint him to the drugs with the same effect. When combined with similar Sparflo number of antimicrobials commonly observed summation of their effect.  Packing Sparflo

Pregnancy and lactation

According to the instructions Sparflo contraindicated in pregnant and nursing mothers.


Care should be taken when making Sparflo persons engaged in potentially hazardous work.

Side effects

Practical reviews of Sparflo showed possible manifestation of the following side effects - loss of appetite, vomiting, nausea, dyspepsia, hepatitis, dizziness, headache, fatigue, drowsiness, increased intracranial pressure, hallucinations, rush of blood to the face, fainting, disturbances of the senses, thrombosis of the cerebral arteries, lengthening the interval QT, itching, swelling of the face and throat, drug fever, shortness of breath, sweating, hyperglycemia.

Storage conditions Sparflo

Sparflo stored in a dry, dark place, away from children at a temperature not exceeding 25 ° C.

Storage life

3 years.