Solian - it is an antipsychotic that has found application in psychiatric practice.
Pharmacological action Solian
Solian belongs to the group of antipsychotics
. Active ingredient - amisulpirid
. It selectively path (has affinity) for dopamine receptors of type 2 and 3 of the limbic system of the brain without interfering with the other receptor types in the body - serotonergic, cholinergic, adrenergic, histamine
. With this amisulpirid exerts its therapeutic effect without causing many adverse and undesirable effects that usually occur during stimulation of these receptors
. Therefore, reviews Solian tolerated much better than haloperidol and its analogues
. The limbic system - a part of the brain responsible for emotions
. Acting on its receptors, Solian has a calming effect, suppresses aggression and agitation
. At the same reaction to external stimuli is reduced
. When mental illness the drug is able to inhibit hallucinations, delirium, automatism, providing a positive therapeutic effect on patients
Solian - atypical, different from other neuroleptic antipsychotic drug. Drug dose-dependent effect of it - in high doses ranging from 400 mg / day, it blocks postsynaptic receptors, and has a positive impact on the productivity of the disease symptoms (delusions, hallucinations). At low doses (50 - 300 mg / day) Solian connected to presynaptic dopamine receptors, thereby eliminating the negative symptoms (lack of emotional care of the communication).
Solian instructions on does not have a soporific effect, but can contribute to a more rapid onset of sleep and slumber. Solian Review enhances the effect of hypnotics, narcotics, local anesthetics, and reduces the effect of taking psychostimulants. This drug is practically not metabolized in the liver and excreted from the body by the kidneys unchanged. Therefore, it does not adversely affect the liver, but in renal pathology removing it slows down, so need a smaller dose Solian and constant medical supervision.
Solian available in tablets of 100, 200 and 400 mg, 5% solution in vials for intramuscular injections and the solution inside the bottles of 100 ml.
According to the instructions Solian is used in the treatment of schizophrenia. This mental disease progresses gradually, manifesting a change in thinking, perception, speech, feelings of social activity. In people, it is known as a "split personality." Solian eliminates both productive symptoms of delusional thinking and speech, hallucinations, thought disorders and negative - reduced emotional activity, reducing contact with others, the flattening of affect.
Solian prohibited intolerance of its components, in cases prolaktinzavisimyh tumors, tumors of the adrenal cortex (pheochromocytoma), during pregnancy and lactation in humans molozhe18 years (since not conducted clinical trials), and severe renal insufficiency. The drug is not recommended for use with quinagolide, levodopa, antiarrhythmics class 1A and 3, cisapride, some antibiotics for intravenous administration, etc..
Carefully and always under the constant supervision of a doctor should be treated with this drug in patients with certain types of cardiac pathology (bradycardia, ventricular arrhythmia), renal failure in the early stages of her, diabetes, in the elderly, especially dementia, Parkinson's disease, a predisposition to stroke and thromboembolism.
Instructions for use Solian
The drug is taken orally, and the dose rate at different stages of change and expects psychiatrist.
If the dosage Solian no more than 400 mg / day, you can receive money only once a day, if it is more - it is necessary to divide it into 2 admission. Usually, if the predominant negative symptoms in the form of lower communication and socialization, the dose Solian is 50 - 300 mg / day when administered (median 100 mg), it picked individually.
During acute psychotic episodes with productive symptoms, treatment begins with an introduction into the muscle Solian a few days up to 400 mg / day, and then move on to oral an average of 400 - 800 mg per day, the maximum allowable dosage of 1 to 2 g / day.
If sustained improvement of health of the patient remains on the individual maintenance dose of the drug.
Side effects Solian
Depending on the frequency of registration of adverse effects from the treatment Solian divided into very frequent, frequent, infrequent, rare and very rare. Sometimes it is difficult to separate side effects from the symptoms of schizophrenia.
CNS can occur extrapyramidal disorders (tremor, dyskinesia, hypersalivation, etc..), Acute dystonia (spasmodic torticollis, lockjaw, and others.), Daytime sleepiness, seizures, tardive dyskinesias muscles of the face and tongue.
From the change of mentality in the form of sleep disorders, excessive anxiety, agitation.
On the part of the digestive tract - constipation, vomiting and nausea, with the endocrine system - galactorrhea, amenorrhea, gynecomastia, erectile dysfunction, cardiac and vascular - reducing pressure and heart rate in the blood - leukopenia, and agranulocytosis.