Sermion - a drug that promotes improvement of cerebral and peripheral blood circulation.
Pharmacological action Sermion
The active substance Sirmione - nicergoline, has alpha1-adrenoceptor blocking effect of improving peripheral and cerebral circulation.
Application Sermion reduces platelet aggregation, improve the hemodynamic and metabolic processes in the brain and blood rheological parameters of blood, as well as increase the rate of blood flow in the upper and lower extremities.
Sermion acting on instructions slowly and require prolonged use.
Sermion produced in the form:
- Round orange coated tablets containing 5 mg (15 pieces in a blister), 10 mg (25 pieces in a blister) and 30 mg (15 pieces in a blister) of the active substance - nicergoline. Excipients - Sodium carboxymethyl cellulose, calcium hydrogen phosphate dihydrate, magnesium stearate, microcrystalline cellulose;
- Lyophilisates for solution for injection (powder or porous mass of white), with attached solvent. In vials containing 4 mg of nicergoline. Excipients - tartaric acid or lactose monohydrate.
Analogues of Sirmione on the active substance are medicines and Nicergoline Sermion (in pill form) and Nicergoline-Verein (in the form of a lyophilisate for solution).
By analogues Sermion mode of action include drugs Vazobral, dihydroergocristine mesylate and Redergin.
According to the instructions Sermion indicated for use in acute and chronic cerebral metabolic and vascular disorders resulting from:
- Thrombosis or cerebral embolism;
According to the testimony Sermion prescribed for:
- Acute transient cerebral circulatory disorders;
- Headaches caused by vasospasm;
- Vascular dementia.
Also, the use Sermion effective in treating:
- Organic and functional arteriopathies limbs;
- Syndromes associated with disturbed peripheral blood flow;
- Raynaud's disease.
In some cases Sermion and analogues of the drug administered parenterally as an additional tool for the treatment of hypertensive crisis.
Sermion contraindicated for instructions used in the following cases:
- Recent acute myocardial infarction;
- Violations of orthostatic regulation;
- Acute bleeding;
- Hypersensitivity to nicergoline.
According to the testimony Sermion can be used during pregnancy only under medical supervision, because the safety of using the drug during this period has not been studied.
Application Sermion lactation is not recommended.
In the opinion of Sermion prescribed with caution in gout and hyperuricemia in history, as well as in combination with drugs that violate the metabolism and excretion of uric acid.
The method of administration, the duration and dose Sermion instructions depend on the nature of the disease. In some cases, treatment is initiated with parenteral administration, and then transferred to the dosage form of tablets (for maintenance treatment).
Tablets Sermion on instructions received via regular intervals three times a day in a dose of 5 to 10 mg.
The time of application is determined by the doctor, but in most cases it is at least several months.
In the treatment of vascular dementia Sermion on indications administered in a dosage of 30 mg twice a day. Every six months of treatment is recommended to consult a physician to determine whether to continue the therapy.
Intramuscular application Sermion shown in a dosage of 2-4 ml, 2 times per day.
Intravenous drug is injected slowly at a dose of 4-8 mg diluted in 100 mL of 5-10% dextrose or 0, 9% sodium chloride solution. According to the testimony Sermion this dosage may be administered several times a day.
Intraarterially usually administered 4 mg, dissolved in 10 ml of sodium chloride solution (0 9%) for 2 minutes.
If the kidney function dose Sermion Review reduced.
When Sermion overdose may lead to a marked reduction in blood pressure. Special treatment is needed, except in cases of severe disruption of the blood supply to the brain, where it is recommended the use of symptomatic drugs (under the constant control of blood pressure).
Sermion on the testimony should be taken with caution in conjunction with antihypertensive drugs.
Typically, the drug at therapeutic doses has no effect on blood pressure. However, in some cases, hypertension Sermion Review may lead to a gradual reduction in pressure.
Side effects Sermion
As a rule, Sermion Review is well tolerated, and side effects are moderate.
According to reviews Sermion in rare cases it leads to a violation of the cardiovascular system, which is manifested as dizziness, marked reduction in blood pressure and feeling the heat. To avoid the possible appearance of hypotension after parenteral administration Sermion recommended for a few minutes to take a horizontal position.
In some cases, a increase in the concentration of uric acid in the blood (regardless of the duration of therapy and received a dose of the drug).
In addition, reviews of Sermion can cause:
- Drowsiness or insomnia;
- Skin rashes;
- Dyspeptic symptoms.
Sermion - prescription drugs, referring to the list B. Do not exceed the shelf life of the product: for a lyophilized powder for injection - 4 years, for tablets - 3 years.