Sandostatin - drugs used in gastroenterology.

Pharmacological action

Sandostatin - is a synthetic derivative of the hormone somatostatin, which suppresses the action of growth hormone, called insulin-induced hypoglycemia, physical activity and arginine; production of gastrin, glucagon, insulin, caused by ingestion or arginine; production of thyrotropin - pituitary hormone.

 Sandostatin in carton

Product form

Solution for injections.

Indications Sandostatin

Sandostatin is used to treat acromegaly - a disease in which there is disproportionate growth of internal organs, tissues, skeletal. Sandostatin people with this disease is prescribed in those cases where the treatment by radiation therapy, surgery, dopamine antagonists reception failed. Use of Sandostatin enables control of symptoms of the disease and reducing the level of somatomedin, and growth hormone (GH).

The instructions Sandostatin also pointed out that it can be administered in the presence of endocrine tumors in the gastrointestinal tract or pancreas - it reduces the severity of symptoms; when gastrinoma, Vipom, carcinoid tumors, glucagonomas, insulinoma, somatoliberinomah; for refractory diarrhea in those who are ill with AIDS.

Sandostatin also effective in cases where the need to stop or prevent bleeding varices of the esophagus or stomach in patients with cirrhosis and after surgery on the pancreas - to prevent the development of complications.

Sandostatin Guide: how to use

Patients with acromegaly early treatment is administered 0, 05-0, 1 mg of Sandostatin subcutaneously every 8 or 12 hours. Holds monthly tests for growth hormone, analyzed the clinical picture and depending on the data obtained, the dosage may be increased to 0, 2-0, 3 mg. More than 1, 5 mg per day is not recommended to take the patient. According to the instructions of Sandostatin treatment should be stopped if after three months will not be seen sufficiently reduce the GR and improvement.

Patients with tumors of the endocrine pancreas, and the gastrointestinal tract is administered 0, 05-0, 1 mg of the drug per day.

For the treatment of persistent diarrhea among those who are sick with AIDS, administered 0, 3 mg Sandostatin. If after a week the condition does not improve, the dose may be increased up to 0, 75 mg. Treatment is stopped if the dosage and application a week no effect.

For the prevention of complications after surgery on the pancreas Sandostatin administered in a dosage 0, 3 mg per day.

To stop the bleeding from veins of the stomach or esophagus of intravenous infusion - administered 25 mg / h for five days.

side effects


Sandostatin may cause anorexia, abdominal distension, diarrhea, abdominal cramps, nausea, pancreatitis, acute intestinal obstruction (rare).

Due to the prolonged use of Sandostatin may appear gallstones, develop hyperglycemia.

Not excluded the possibility of local reactions at the injection Sandostatin under the skin - it can be a pain, burning, swelling, redness, itching. These symptoms are usually tested for 15 minutes.


The instructions Sandostatin stated that it is contraindicated in case of hypersensitivity during breastfeeding, pregnancy.

Patients with diabetes and cholelithiasis take the medicine with caution.