Rovamycinum - antibacterial medication from the group of macrolides.
Structure and Composition
According Rovamycinum instructions issued in the form of tablets, coated in form of a lyophilisate for solution for injection. The active ingredient - spiramycin. In 1 tablet contains 1, 5 million., Or 3 million IU. IU of the active substance. Also includes auxiliary components: colloidal silicon anhydrous, magnesium stearate, prozhelatinizirovanny starch, croscarmellose sodium giroksipropiltsellyuloza microcrystalline cellulose.
Externally Rovamycinum a white round biconvex tablets. Produced the drug in a blister. Rovamycinum to 1, 5 million. ME is released on 8 tablets in a blister, 3 million. ME - 5 tablets in a blister. The carton 2 blisters.
Rovamycinum as a lyophilisate for solution for intravenous administration is available in bottles of 1, 5 million. IU. The carton 1 vial of the drug.
Pharmacological action Rovamycinum
According to the instructions Rovamycinum has an antibacterial effect. The drug inhibits protein synthesis in bacterial cells and has a bactericidal or bacteriostatic effect (depending on dose).
Most sensitive to Rovamycinum following microorganisms: Streptococcus (sensitive metiltsillinu), staphylococci, enterococci, pertussis bacillus, Helicobacter pylori, Legionella, Campylobacter eyuni, korinobakterii diphtheria, mycoplasma, chlamydia, pale treponema, Borrelia, Leptospira, actinomycetes, peptostreptokokki, eubacteria. Moderately sensitive to Rovamycinum gonorrhea, Clostridium perfringens, ureoplazma.
Clinically proven Rovamycinum against the pathogen of toxoplasmosis.
This drug accumulates in phagocytes (monocytes, neutrophils, alveolar macrophages), which explains the efficiency Rovamycinum against intracellular bacteria (Chlamydia, Toxoplasma, Mycoplasma).
According to the instructions Rovamycinum absorbed quickly, but not completely. The drug crosses the placental barrier and diffuses into breast milk. In spinal fluid penetrates Rovamycinum.
This drug is excreted in the bile, kidneys displayed only 10%. The half leaves 8 hours.
According to the instructions Rovamycinum indicated for use in the following situations:
- infectious and inflammatory diseases of the respiratory tract (tonsillitis, sinusitis, bronchitis, pneumonia);
- infectious and inflammatory diseases of the skin and soft tissues (erysipelas, erythrasma, secondary dermatitis, cellulitis, abscesses);
- infectious-inflammatory diseases of bones and joints (except for gonococcal arthritis and osteomyelitis of origin);
- infectious and inflammatory diseases of the genitourinary system;
- toxoplasmosis (including pregnant women);
- prevention of relapse (relapse) articular rheumatism patients allergic to penicillin.
- Hypersensitivity to the ingredients of the drug;
In patients with a deficiency of the enzyme glucose-6-phosphate is not recommended to use Rovamycinum as possible the development of acute hemolysis.
Precautions This medication should be used in patients with bile duct obstruction and symptoms of liver failure (since Rovamycinum mainly excreted in the bile).
According to reviews Rovamycinum rarely causes side effects.
From the digestive system may cause nausea, vomiting, diarrhea. In very rare cases (less than 0, 01%) had the appearance of pseudomembranous colitis, cholestatic hepatitis.
Cardio - vascular system may occur on the electrocardiogram extended interval QT.
From the nervous system Rovamycinum, reviews, very rarely leads to the appearance of transient paresthesias.
From the hematopoietic system is extremely rare (less than 0.01%) were cases of acute hemolysis and thrombocytopenia.
Rovamycinum, reviews, rarely causes allergic reactions (rash, pruritus, urticaria). Severe hypersensitivity reactions (angioedema, anaphylactic shock) have been reported rarely (less than 0, 01% of cases).
Application Rovamycinum during pregnancy and lactation
According to the instructions Rovamycinum during pregnancy can be used according to indications. If the drug must be assigned during lactation, the breast-feeding should be discontinued during treatment Rovamycinum.
Dosing and Administration
According to the instructions Rovamycinum tablets Adults appoint 3 million. 2-3 times a day. The maximum daily dose - 9 million. IU.
For children, the tablets are used for 1, 5 million. IU. The daily dose is calculated based on the body weight of 150-300 thousand formula. IU / kg body weight of the child. The maximum dose for children Rovamycinum 300 thousand. IU / kg per day.
Rovamycinum for parenteral administration should be administered by slow intravenous injection of 1, 5 million. IU 3 times a day. In case of severe infection dose may be doubled. Children Rovamycinum applied only in tablet form.
Patients with impaired renal function dose adjustment is not required Rovamycinum.
There is no data on overdose Rovamycinum. If you suspect an overdose of the drug should be symptomatic treatment (gastric lavage, chelators).
Interaction with other drugs
In an application Rovamycinum with levodopa dosage adjustment is necessary levodopa and clinical monitoring (since the concentration of the drug in the blood serum can be reduced).
Special instructions for use Rovamycinum
According to the instructions given drug has no teratogenic effects, so you can assign Rovamycinum during pregnancy. In the treatment of toxoplasmosis in pregnant this drug is marked reduction in the risk of transmission to the fetus: I trimester from 25% to 8%, in II trimester from 54% to 19%, and in the III trimester from 65% to 44%.
Application Rovamycinum in patients with liver disease requires monitoring of its function during therapy.