Reserpine - an antihypertensive and antipsychotic drug.  Formula reserpine

Product form

The drug is available in tablet dosage of 0, 1 and 0, 25mg.

Reserpine analogs are drugs, as part of which has the same active ingredient: Adelfan-Ezidreks, Alserin, Relsidreks-G, Trirezid-K Rausedil, Rausedan, Kristoserpin, Rau-Sed, Serfin, Serpas, Tenserpin, Gipnoserpin et al. Includes reserpine as part of the antihypertensive action of certain drugs, such as Kristepina.

Pharmacological action

The active ingredient of the drug is reserpine, one of the alkaloids of Rauwolfia plant snake (Rauvolfia serpentina) .  Reserpine is Simpatolitiki, t . e .  has a preferential effect on the sympathetic nervous system, inhibiting it, and as compensation for activating the parasympathetic .  It causes a persistent drop in blood pressure, largely due to the inactivation of MAO .  Antipsychotic effect of reserpine is based on reducing the concentration of the neurotransmitters (serotonin, dopamine, and so on . P . ) In neurons .  Reduces heart rate, reduces the total peripheral vascular resistance, contributes to the deepening of the physiological sleep potentiates the effect of sleeping pills and painkillers .  The use of reserpine slows down metabolism in patients suffering from hypertension and coronary atherosclerosis, normalizes protein and fat metabolism .  Under the influence of the drug, breathing becomes deeper and yet more rare miosis occurs (miosis), reduced body temperature .

Reserpine activates the production of hydrochloric acid the stomach, increases peristalsis, increases renal blood flow, improves glomerular filtration in the kidneys.

This drug has a cumulative effect: the primary effect observed after a few days after the start of reserpine, peaking only after 3-6 weeks of regular admission. The drug is excreted from the body within 1-6 weeks.

Indications reserpine

Indications for use of reserpine is primarily resistant hypertension, this drug is a list of the most important means for the treatment of hypertension in the early stages. Also means effective for symptoms of late gestosis, accompanied by an increase in blood pressure, hyperthyroidism, heart failure mild, followed by a moderate tachycardia.

Earlier indications for the use of reserpine considered mental illnesses: psychosis, schizophrenia, accompanied by agitated, manic phase TIR depressive agitation in patients with senile psychosis and neurosis, and neurosis-like states. Currently, however, the use as an antipsychotic agent reserpine limited, it is practically used in view of a more efficient and fast formulations.

Instructions for use of reserpine

The drug is taken orally after a meal, it is necessary to wash down pills with plenty of clean water.

In accordance with the instruction assigned reserpine in treating early stages of hypertension in the following dosage:

0, 1mg per day, 2 times - in the morning and evening for 5-7 days. In the absence of a therapeutic effect during this time, the dosage is increased depending on the indication, if necessary, adjusting the daily dose of 0, 5 mg, divided into 2 doses. When the patient's condition has stabilized, and blood pressure reached normal values, the dose was gradually reduced, back to 0, 1 mg per day as a maintenance therapy. The course of treatment is 2-3 months.

The drug for other indications (late preeclampsia, tachycardia, hyperthyroidism and so on.) Is assigned in the complex therapy, and therefore it is necessary to take into account its interaction with other drugs. In this case, according to instructions by reserpine assigned individual scheme, in accordance with the instructions of the attending physician.

Reserpine approved for use in pediatric practice, the dosage is established by the attending physician on an individual basis depending on the evidence.  Adelfan-Ezidreks - analogue of reserpine

Side effects

The use of reserpine may have the effect of the following adverse effects:

  • Nervous system - headache, dizziness, sleep disturbance, anxiety, weakness, fatigue, hyporeflexia, deterioration of concentration, depression, extrapyramidal disorder, decreased libido;
  • From the digestive system - signs of dyspepsia, epigastric pain, loss of appetite, dry mouth, gastrointestinal bleeding (rare);
  • Cardio-vascular system - arrhythmia, bradycardia, erectile dysfunction, pain in the retrosternal space, redness of the sclera;
  • From the urinary system - a violation of water-salt metabolism (peripheral edema, swelling and dryness of mucous membranes), dysuria, anuria;
  • For the skin - rash, itching, worsening of herpes infection;
  • On the part of metabolism - weight gain.

In case of overdose of this drug, in addition to the above, the following symptoms: parkinsonism, nightmares, abnormal liver function, angina.

Contraindications to the use of reserpine

In accordance with the instructions of reserpine is contraindicated in the following situations:

  • Individual hypersensitivity;
  • Parkinson's Disease;
  • Epilepsy and seizures epileptopodobnye history;
  • Depression;
  • Gastric ulcer and duodenal ulcer in the acute stage;
  • Ulcerative colitis;
  • Gastritis;
  • Bronchial asthma;
  • Angle-closure glaucoma;
  • Myxedema;
  • Congestive heart failure;
  • Atrioventricular block;
  • Bradycardia;
  • Pheochromocytoma;
  • Atherosclerosis and coronary vessels of the brain;
  • Nephrosclerosis;
  • Pregnancy;
  • Breast-feeding.

Reserpine is not appointed during electroconvulsive therapy treatment MAO inhibitors.


Concurrent administration of other drugs at the time of application of reserpine requires medical supervision, as with many of them, he shall enter into unwanted interactions, reducing, increasing or altering the therapeutic effect.

Before the planned surgery reserpine treatment is stopped for a few days before the intervention, if necessary, emergency surgical treatment in patients receiving reserpine necessary to atropine premedication.

The drug reserpine reduces attention and slows reaction and during therapy because they perform potentially dangerous, requiring quick response work, desirable. You should also be careful when driving a car in this period, doctors recommend give up driving at the time of treatment.

Storage and release

Reserpine stored in tightly packed, dry, out of direct sunlight, at room temperature for 3 years.

Keep away from the reach of children!

Sold by prescription.