Reopirin - combined pharmacological agents from the group of non-steroidal anti-inflammatory drugs.

Structure and Composition

 Reopirin solution
 According to the instructions Reopirin issued in the form of pellets and a solution for injection. Active ingredients - sodium and phenylbutazone aminophenazone.

In the 1 tablet contains 125 mg of active substance. The cardboard package contains 2 Valium planimetric packages of 10 pills.

Also available Reopirin ampoules (5 ml). In one ampoule contains 150 mg and 150 mg aminophenazone fetilbutazona sodium. The carton contains 5 vials.

Pharmacological action reopirin

According to the instructions Reopirin analgesic (painkiller), antipyretic and anti-inflammatory action. The active ingredients of the drug blocking cyclooxygenase (inflammatory mediator), inhibit the synthesis of prostaglandins, inhibit the formation of free radicals. Reopirin reduces the perception of pain, the drug affects the pain impulse transmission and neuronal excitability teploreguliruyuschego center.


Reopirin prescribed for such diseases:

  • non-infectious etiology of acute arthritis (rheumatic, gouty);
  • degenerative diseases of the spine with pain syndrome;
  • ankylosing spondylitis;
  • inflammatory diseases of the extra-articular soft tissues;
  • neuralgia, polyneuritis;
  • retinitis, iritis;
  • polyserositis;
  • pericarditis;
  • adnexitis, Options.

Contraindications reopirin

  • hypersensitivity to the components;
  • heart rhythm disorders, heart disease, cardiomyopathy;
  • severe liver and kidney disease;
  • signs of bone marrow suppression;
  • gastric ulcer and duodenal ulcer;
  • spazmofiliya (for parenteral administration);
  • epilepsy (for parenteral administration);
  • Children under 7 years old.

Use during pregnancy and lactation

According to the instructions Reopirin can cause chromosomal changes in human lymphocytes, so the use of this drug during pregnancy is not desirable. Safety of reopirin during lactation has not been studied.

Dosing and Administration reopirin

According to the instructions Reopirin recommended to prescribe a daily dose of 4-6 pills a day. The drug is taken after a meal, without chewing, drinking plenty of water.

Reopirin ampoules administered intramuscularly (injection should be deep into the gluteus maximus muscle for 2 minutes), 5 ml once a day. The drug is given daily or every other day.

Children (7-14 years) Reopirin designate the interior of ½-1 tablet 3 times a day, or intramuscularly at 0, 5-1 ml. Reopirin Injections should be done every day or every other day. The duration of therapy with this drug is determined by the doctor.  Reopirin dragees

side effect

According to the instructions Reopirin may cause the following side effects: nausea, vomiting, erosive and ulcerative lesions of the gastrointestinal tract, leukopenia (reduction in the number of leukocytes in peripheral blood), the delay of water and sodium, hematuria (blood in the urine), drowsiness, allergic reactions (hives itching, skin rash).

After reopirin injections may cause abscess at the injection site. Currently, the drug is not used because of the high incidence of adverse reactions.

Overdose reopirin

Overdose symptoms in the initial stage - nausea, vomiting (may be blood in the vomit), psychosis, agitation, hallucinations, seizures, hyperthermia. To further develop liver failure, jaundice, changes in the electrocardiogram, agranulocytosis. Treatment - symptomatic (gastric lavage, chelators). There is no specific antidote.

Interaction with other drugs

According to the instructions Reopirin enhances the action of hypoglycemic drugs (tablets), anticoagulants, barbiturates, sulfonamides. Concomitant use reopirin reduces the effect of certain medications (phenytoin, imipramine, cephalosporin, griseofulvin).

Analogs reopirin

Reopirin complete analogy of the active ingredients do not. Phenylbutazone (active substance phenylbutazone) is incomplete analogue reopirin.

precautionary measures

Since the use of reopirin accompanied by an increased risk of complications, the use of this drug to children is justified only in extreme cases (at the hospital for constant monitoring of blood tests and liver function). In cases of long-term treatment with this drug should be weekly to determine the number of leukocytes in peripheral blood. In epilepsy (or suspected) in Reopirin injections are contraindicated.