Propitsil - an antithyroid drug.  Propitsil

Structure and Composition

The drug is released in the form of tablets in a package of 20 or 100 pieces. Each tablet contains the active ingredient - 50 mg propylthiouracil. Auxiliary components: corn starch, pregelatinized starch, magnesium stearate, lactose, povidone, colloidal silicon dioxide.

Pharmacological action

The mechanism of action is associated with inhibition propitsil in the thyroid peroxidase system. It prevents the formation of thyroxine and relieves iodization process thyroglobulin. Because of propylthiouracil in molecules of thyroglobulin is broken between education tirozolnymi residues associated with iodine, pair bonds.

Application propitsil leads to depletion of iodine in the thyroid gland. Under the influence of the drug decreases the formation of thyroxine to triiodothyronine in peripheral tissues.

Indications propitsil

According to the instructions propitsil prescribed for:

  • hyperthyroidism with diffuse toxic goiter;
  • toxic adenoma of the thyroid gland;
  • preparations for the treatment of radioactive iodine;
  • preparation for surgery on the thyroid gland.

Dosing and dosing regimen propitsil

Propitsil for instructions intended for ingestion. Children older than 10 years and adults at the beginning of treatment prescribed by 1, 5-2 tablets (75-100 mg) per day. In severe cases, and the load after a preceding elementary iodine propitsil dosage according to the instructions of 6-12 tablets (300-600 mg) per day, divided into 4-6 doses.

The maintenance dose is 0, 5-1 tab. Propitsil (25-50 mg) per day.

The interval between doses tablets propitsil during the day is 6-8 hours.

Neonatal thyrotoxicosis administered propylthiouracil the rate of 5-10 mg per kg of body weight per day in three divided doses. In the absence of results of treatment the dosage is increased by 50-100%. Maintenance Dosage thyrotoxicosis neonatal - 3-4 mg per kg of body weight per day.

The duration of therapy is determined individually Propitsilom.

Reviews Propitsile show that adenoma of the thyroid gland, as well as hyperthyroidism with diffuse toxic goiter duration of treatment is not less than one and a half to two years.

In preparation for the treatment of radioactive iodine and thyroid resection length of the course of the drug is determined individually.  Propitsil pills

side effects

In the opinion of propitsil cause the following side effects of the various systems of life:

  • hives, skin rash.
  • vomiting, nausea, disturbances of taste sensitivity, stomach pain;
  • an increase in the size of the thyroid gland;
  • agranulocytosis, hemolysis, disorders of erythropoiesis;
  • neuromuscular disorders, dizziness;
  • arthritis, periarteritis nodosa, arthralgia with no signs of inflammation of the joints, a positive Coombs' reaction, alopecia, peripheral edema, interstitial pneumonia.

The use of high doses of reviews propitsil can cause liver damage, lymphadenopathy, drug fever, thrombocytopenia.


According to the instructions propitsil is contraindicated in:

  • hypothyroidism;
  • hypersensitivity to propylthiouracil;
  • cirrhosis, active hepatitis, abnormal liver function;
  • agranulocytosis, leukopenia.

Application propitsil during pregnancy and lactation

Diseases such as hyperthyroidism and hypothyroidism in pregnant women are characterized by an increased incidence of stillbirth, miscarriage and fetal anomalies.

In the treatment of propylthiouracil fetal anomalies frequency corresponds to the frequency of spontaneous abnormalities. Propitsilom Treatment during pregnancy is possible only under the strict supervision of a physician-endocrinologist. The level of thyroid hormones the patient should be at the upper limit of normal, and the level of TSH - below the norm.

Pregnant women are prescribed according to the instructions in propitsil minimum allowable dose to avoid miscarriage, as well as the development of goiter and hypothyroidism in the fetus. In the third trimester of pregnancy symptoms of hyperthyroidism are often reduced.

When breastfeeding propylthiouracil is the treatment of choice. Despite the fact that its content in breast milk is only one tenth of the level in the blood serum of the mother, the newborn should be carefully monitored, as there were reviews of Propitsile showing the development of hypothyroidism in children.


In the opinion of propitsil not cause acute intoxication. In chronic overdose propylthiouracil is the development of hypothyroidism and thyroid enlargement in volume. In this case, the drug should be discontinued.

Drug Interactions

Thyreostatic action propitsil reduced or in combination with the previous use of drugs containing iodine or x-ray contrast agents.

Due to the fact that propylthiouracil can exert the effect on the action of free active fractions coumarin derivatives and propranol, additionally to adjust the dose of these drugs.

Conditions and terms

Keep it propitsil in a cool dry place for no longer than 36 months.