Promedol formula

Pharmacological action

Promedol is a potent drug, intended for the relief of pain. The active ingredient of the drug has on the human body the same effects as the natural narcotic alkaloid morphine, but the power of action and its severity is somewhat lower. The drug prevents the onset of a painful shock resulting from injury or disease states of the body, relaxes the smooth muscles of hollow muscular organ, but increases muscle contraction of the pregnant uterus, allowing to stimulate and labor analgesia used Promedol - indication for weak labor will slow and cervix uterus. In addition, the drug has a mild sedative and hypnotic effect, the duration of which depends on the individual characteristics of the human body.

The mechanism of action is due to the interruption of promedol interneurons transmit the pain impulse - this drug is only temporarily relieves pain without causing any impact on the cause of its occurrence, and changes the ratio of the patient's pain. Promedol less than morphine affects nerve centers of the CNS, respiratory depression and therefore vomiting occur less frequently. Usually the drug is administered intramuscularly or intravenously - in this case, the analgesic effect promedol Review patients occurs within 15-20 minutes, and stored for 4 hours after the administration, but using promedol for epidural analgesia in labor its action may persist for 6-8 hours . In addition, it is possible the drug inside a pill.


Application promedol justified to eliminate pain of moderate strength, or expressed, for example, to eliminate postoperative pain, pain arising in myocardial infarction or thrombosis of major vessels, pericarditis and pleurisy, spontaneous pneumothorax, and air embolism that occurs on a background of injuries .  The indication for pain relief is promedol arising complications of gastric ulcer and duodenal ulcers, and acute exacerbation of chronic pancreatitis, renal and hepatic colic, urological diseases .  In neurology drug used for the relief of pain in neuritis, causalgia (phantom pain), severe sciatica, injuries and disc protrusion, thalamic syndrome .  Promedol can be used as a means for sedation, and one component of general anesthesia, including for labor analgesia . Indications for use promedol is to facilitate the state of cancer patients .

Instructions for use promedol

Instruction promedol indicates that drug in any form should be administered only by a physician who determines the recommended dose, frequency of administration and the total duration of treatment. In the case where this is not about alleviating the condition of patients suffering from cancer, the duration of treatment should be as limited as Promedol addictive, physical and psychological dependence.

Subcutaneous and intramuscular injected drug, 1-2 ml of 1-2% solution 2-4 times a day depending on the severity of the clinical effect. Administering a dose of the drug starts 20mg (2 ml 1 ml 1% or 2% solution) at one time, and in the course of treatment, it can be adjusted by a physician. The pediatric dose promedol reduced according to the weight of the patient and may be 0, 25 mg / kg. In the case where the indication for pain relief becomes promedol spasm of smooth muscle, the drug can be combined with antispasmodic drugs (burden-pa, papaverine).

Instruction promedol when labor analgesia indicates that the drug is administered subcutaneously or intramuscularly, controlling condition of the mother and fetus. A single dose of the drug can be 4 ml of 1% or 2 mL of 2% solution (40 mg), but the drug should be administered at least 40-60 minutes before the start of the period of attempts (the disclosure of uterine throat than 8 cm Promedol not introduced in order to avoid the development of respiratory failure in newborn). Depending on the severity of the condition number of administrations of the drug can be changed (in which case you need to remember about the possibility of addiction). Instruction promedol indicates that intravenous drug prescribed in exceptional cases (for the relief of acute pain with injuries), but in this case, the duration of action is considerably shorter.


 Promedol kit

Application promedol contraindicated if you are hypersensitive. The drug is not prescribed for the already existing depression of the respiratory center, and are not used for spinal or epidural anesthesia for existing bleeding disorder. Doctors in a review of promedol indicate that the drug should not be administered concurrently with MAO inhibitors, used to treat diseases of the nervous system, asthma, high blood pressure, heart rhythm disturbances, central nervous system depression, regardless of its cause. Promedol wary appoint patients with renal and hepatic failure in pediatric or elderly patients.

side effects

The most common side effects that occur in the background promedol use are:

  • on the part of the digestive system - dry mouth, nausea and vomiting, constipation, signs of liver toxicity;
  • the nervous system - dizziness, drowsiness, weakness, headache, muscle trembling, nervousness, fatigue, confusion, convulsions, euphoria;
  • from respiratory - depression and hypoxia;
  • the part of the circulatory system - unstable blood pressure, heart rhythm disturbances;
  • allergic reactions and drug idiosyncrasy

Analogs promedol

Promedol analogues are natural and synthetic opioids - morphine, Omnopon, Tramdol, STADOL, Fentanyl. Doctors in a review of promedol said that to reduce the likelihood of side effects of this drug can be combined with antispasmodic drugs. To reduce the risk of addiction must be as soon as possible if the patient's condition allows, replace Promedol an effective non-narcotic analgesics - Ketanov, Deksalgin, Bonifen.


The systematic application of promedol can cause dependence. The drug should not be administered concurrently with other drugs that depress the nervous system. During treatment should abandon any activities that require quick response. In the process of receiving promedol strictly forbidden to take drinks of any composition and strength. Treatment is carried out under the constant supervision of a physician.

The preparation is stored and released in accordance with the requirements to list A (toxic and narcotic drugs) only by prescription.