Proginova - pharmacological agents for hormone replacement therapy used in the treatment of estrogen deficiency of menopause complications.  Proginova

Structure and Composition

According to the instructions Proginova issued in the form of pills. The active ingredient - estradiol valerate in 1 tablet formulation contains 2 mg of estradiol. Also the preparation Proginova includes auxiliary components - lactose monohydrate, corn starch, polyvidone, magnesium stearate, talc, sucrose, macrogol, calcium carbonate precipitate, titanium dioxide, glycerine, yellow iron oxide pigment, montan wax.

In 1 package contains 21 Proginova pills in a blister pack, the calendar dial and the instructions for use.

Pharmacological action Proginova

According to the instructions Proginova up for the deficit of endogenous estrogen, helps reduce blood cholesterol and low density lipoprotein (LDL) cholesterol in the blood. This drug helps to stop climacteric symptoms during periods of pre - and post-menopause, and also after the surgical removal of the ovaries (oophorectomy). Admission Proginova prevents a decrease in bone mass and osteoporosis.


According to the instructions, Proginova recommended when estrogen deficiency (which is accompanied by symptoms such as - hot flashes, sleep disturbances, sweating, irritability, depression, headache, dizziness, bladder hypersensitivity, changes in the skin and mucous membranes) in the postmenopausal period, after ovariectomy, radiation castration. Also, the drug can be taken for the prevention of postmenopausal osteoporosis.

Contraindications Proginova

Hypersensitivity to the ingredients of the drug Proginova expressed by the human liver syndrome Rothera Johnson syndrome, liver tumors, breast cancer, hormone-dependent tumors of other sites (including for suspected them), endometriosis, thrombosis and thromboembolism (eg, heart attack, stroke, including history), bleeding from the genital tract of unknown origin, severe hypertriglyceridemia, sickle cell anemia, diabetes with severe, otosclerosis.

Use during pregnancy and lactation

Admission Proginova contraindicated in pregnancy. If there is a need for this drug in women who are breast-feeding, at the time of treatment Proginova breastfeeding should be stopped.

Dosing and Administration Proginova

Before taking Proginova need to be examined by a gynecologist (including breast examination).

Typically, the drug is given 1 tablet a day after meal inside. After receiving Proginova within 21 days of a break of at least 7 days.

The physician can individually assign lower dose (1 tablet a day Proginova).

The time of day does not matter to receive the drug, but it is better to take Proginova in the same hours.  Proginova dragees

side effect

In the opinion of Proginova in most cases well tolerated by patients. Rarely may experience side effects such as a feeling of tension of the mammary glands, nausea, epigastric pain, headaches, weight gain. Very rarely there may be uterine bleeding.

Reasons for immediate discontinuation Proginova

Admission Proginova should be discontinued immediately in such cases:

  • the emergence of strong migraine headaches (the first time);
  • sudden hearing loss or vision;
  • thrombophlebitis or thromboembolic appearance of symptoms (such as pain in the lower extremities, swelling, redness along the venous trunks);
  • the sudden appearance of shortness of breath, feeling pain in the chest;
  • planned operations (drug must stop taking 6 weeks);
  • Immobilization of limbs after injury (eg, hip fracture with plaster immobilization);
  • jaundice, severe itching all over the body;
  • marked increase in blood pressure;
  • increased frequency of epileptic seizures.

Interaction with other drugs

According to the instructions Proginova can modify the action while taking barbiturates, rifampin, ampicillin. Therefore, you should consult with your doctor before the combination of these drugs.

Application Proginova can change the patient's need tablets hypoglycemic agents or insulin.

Special instructions for use Proginova

If the patient has diabetes, hypertension, varicose saphenous veins of the lower extremities, otosclerosis, epilepsy, porphyria, tetany, multiple sclerosis, it is necessary before taking this medication consult your doctor.

If you experience uterine bleeding in patients receiving Proginova need to seek medical attention immediately.

In the opinion of Proginova in very rare cases may contribute to benign / malignant tumors of the liver, which in some cases appear intraperitoneal bleeding. Therefore, when a strange sensation in the upper abdomen should seek medical advice as may be necessary to cancel this drug.