Pregnil - hormonal drug used to treat infertility, late puberty.
Pharmacological action pregnene
The drug has Pregnil similar to luteinizing hormone biological activity. The active ingredient of the drug - human chorionic gonadotropin, which is essential to the formation of sex hormones, maturation of male and female gametes.
Women Pregnil prescribed to stimulate the maturation of follicles in the phase leading to ovulation and for the replacement of endogenous LH during the luteal phase.
Boys and men Gonadotropin needed to produce testosterone - it stimulates the Leydig cells.
Solution for subcutaneous and intramuscular injections.
Analogs pregnene - drugs Ekostimulin, Horagon, Profazi.
Women Pregnil prescribed for infertility caused by a violation of the process of follicular maturation or lack of ovulation; for the preparation of follicles for puncture in front of ovarian hyperstimulation; to maintain the luteal phase.
Men and boys Pregnil prescribed for hypogonadism, delayed puberty, caused by insufficient production of pituitary gonadotropins.
There are good reviews about Pregnile, its effectiveness in cryptorchidism (absence of a testicle in the scrotum), the cause of which was hormonal, anatomical pathology instead.
Instructions pregnene: how to use
When infertility caused by the absence or lack of ovulation follicle maturation, Pregnil administered at a dosage of 000 IU 5000-10.
With artificial insemination, to stimulate the luteal phase do 2-3 injections of 1000-3000 IU. Carry injection pregna for 9 days after embryo transfer or ovulation.
Men and boys in the hypogonadotropic hypogonadism administered to 2,000 IU pregnene two or three times a week.
If male hypogonadism lead to infertility, according to instructions Pregnil administered with follitropin, inject two or three times a week. In order to improve spermatogenesis, the man must take the medicine not less than three months. Testosterone replacement therapy is stopped at this time. Judging by the reviews of Pregnile, in some cases after spermatogenesis improve treatment can limit the intake of human chorionic gonadotropin.
If cryptorchidism children administered the drug for 1, 5 months, twice a week, the boys are introduced to two years 250 IU; boys under 6 years old are introduced 500-1000 IU; the boys after 6 years - 1500 IU. If necessary, re-treatment is carried out.
Late puberty caused by violation of gonadotropic pituitary function, Pregnil administered at a dose of 1500 IU two or three times a week. The treatment lasts six months.
Pregnil and analogues medications can cause fever or rash on the body.
Women taking the drug may complain of abdominal pain, diarrhea, nausea, breast tenderness. In addition, women with treatment Pregnilom may develop ovarian hyperstimulation, and as a consequence - ascites (accumulation of fluid in the peritoneum), hydrothorax (fluid accumulation in the pleural cavity), or increase the appearance of cysts in the ovaries, weight gain.
Reviews Pregnile from taking his men indicate that they drug may cause retention of sodium and water, benign breast enlargement (gynecomastia). These side effects can develop and take medication boys.
Pregnil of instructions can not be taken in cases of suspected hormone-dependent tumors of the breast, ovary, uterus, prostate.
Boys should not be given the drug during early puberty.
Women Pregnil and analogues pregnene contraindicated in the presence of fibroid in the uterus malformation of the genitals.
During breastfeeding, pregnancy can not take human chorionic gonadotropin.
Be wary appoint Pregnil women prone to thrombosis, as it can cause thromboembolism, and patients with heart failure, high blood pressure, kidney damage, migraine, epilepsy.
Drug interaction pregnene not been studied.
Women need to take into consideration that during treatment and within 10 days after its completion, a pregnancy test based on the determination of the content of human chorionic gonadotropin in urine or blood may give false positive response.