Predizin - medicines used in the treatment of diseases of the cardiovascular system.
Pharmacological action Predizina
The active substance Predizina - trimetazidine, has antihypoxia action, optimizes metabolism and function of cardiomyocytes and neurons has cytoprotective effect, support myocardial contractility, prevents a decrease in intracellular phosphocreatine and adenosine triphosphate. Use of the drug in acidosis conditions leads to normalization of the operation of membrane ion channels, prevents the accumulation of sodium and calcium ions in cardiomyocytes and normalizes the intracellular potassium ions.
According to the instructions, Predizin produce a film-coated, round, biconvex tablets with prolonged action, pink color, 10 pc. in blisters in cardboard packs.
One tablet contains 35 mg Predizina trimetazidine dihydrochloride, 88, 22 mg of microcrystalline cellulose, 36 mg hypromellose 04, 88, 22 mg of pregelatinized starch, 1, 26 mg of colloidal silicon dioxide, and 1, 26 mg of magnesium stearate.
The composition includes a coating film 7, 5 mg Opadry II 85G24057, 3, 3 mg of polyvinyl alcohol, 1, 5 mg talc 1 mg Titanium dioxide 46025, 926, 25 mg of macrogol 3350, 262, 5 g soy lecithin, 27, 75 g dye iron oxide red, 19, 5 g of iron oxide pigment yellow and 3, 75 g of iron oxide pigment black.
Predizina analogues of the active substance preparations are:
- Angiozyme retard;
- Antistius MW;
- Vero Trimetazidine;
- Deprenorm MW;
- Medarum 20;
- Rimekor MW;
- Trimitard MW;
By analogues Predizina mechanism of action and of belonging to a group of pharmacological drugs include:
- Doppelgerts Kardiovital;
- Sodium adenosine triphosphate-Vial;
Tablets Predizin prescribed for coronary heart disease in combination therapy to prevent strokes and cochle-vestibular disorders ischemic nature.
In accordance with the instructions, Predizin taken orally morning and evening during meals one tablet of 35 mg.
In accordance with the instructions, application Predizina contraindicated in case of hypersensitivity to the drug, renal failure and severe hepatic impairment. In addition, in accordance with the instructions, Predizin contraindicated in pregnancy and lactation and children under the age of 18 years.
Side effects Predizina
Application Predizina, reviews, causes side effects of the various systems of the body, namely:
- Abdominal pain, nausea, diarrhea, dyspepsia, and vomiting (digestive system);
- Dizziness, extrapyramidal disorders and headache (central nervous system);
- Skin rash, itching, and hives (skin);
- Orthostatic hypotension and rush of blood to the face (cardiovascular system).
Also Predizin, reviews, may cause asthenia.
In accordance with the instructions, Predizin must be stored out of reach of children and protected from light, dry place at room temperature up to 30 ° C. Shelf life of the drug, subject to the recommendations of 2 years.