Polydex (Polydexa) - pharmacological combination drug for the treatment of otitis media.
Structure and Composition
According to the instructions Polydex comes in the form of ear drops. The drug is a combination of corticosteroids (dexamethasone) and antibacterials (aminoglycosides - neomycin and cyclic polypeptide - polymyxin B).
100 ml Polydex comprises: neomycin sulfate 1 g (650000ME), polymyxin B 1000000 IU, dexamethasone sodium metasulfobenzoata 0, 1, besides the principal components of the drug include excipients (citric acid, thiomersal, macrogol, polysorbate, purified water 1 N sodium hydroxide solution).
Externally Polydex solution is clear, light yellow liquid that foams under agitation.
Polydex produced in glass bottles for 10, 5 ml, the kit includes a pipette and instructions for use.
Pharmacological action Polydex
According to the instructions Polydex has antibacterial and anti-inflammatory action. This drug has a damaging effect on the cell membranes of microorganisms, as well as the exchange of breaks within the cell that leads to its destruction. Dexamethasone inhibits the formation of inflammatory enzymes and reduces the permeability of capillaries.
According to the instructions Polydex effectively acts against many gram-negative and gram-positive microorganisms. The drug has no systemic effects while maintaining the integrity of the eardrum.
Indications for use Polydex are the following conditions:
- otitis externa, infected eczema of the external auditory meatus;
- Average acute otitis media.
- Hypersensitivity to the ingredients of the drug;
- perforated eardrum (traumatic or infectious nature).
Use during pregnancy and lactation
Polydex drug is not recommended for long-term use during pregnancy, as there is a risk of ototoxic effects on the fetus.
Dosing and Administration Polydex
According to the instructions Polydex should be instilled into the ear canal. Before using the recommended solution to warm by holding it in your hand. In the opinion of Polydex effectively helps in acute otitis and well tolerated by patients.
This drug should instill 1-5 drops 2 times a day, a course of treatment is 6-10 days. Do not use Polydex more than 10 days. After instillation of the drug is recommended to incline his head for a few minutes, to avoid leakage of drug.
In the opinion of Polydex rarely can cause allergic skin reactions. If you violate the integrity of the eardrum can occur violation hearing and vestibular function.
This drug has a low degree of absorption into the bloodstream, so overdosing is unlikely.
Interaction with other drugs
According to the instructions Polydex not recommended to combine with monomycin, gentamicin, streptomycin, amikacin, netilmicin, as may increase Valium actions.
The analogue is Polydex Polydex with phenylephrine (nasal spray) and maksitrol (combined drug neomycin, polymyxin B and dexamethasone). Talk to your doctor before changing Polydex analogue.
Before applying Polydex make sure that the patient has no perforation of the eardrum, since the use of this drug in this case can result in serious complications such as deafness and vestibular disorders. Contraindicated introduction Polydex pressure. It is not recommended to combine this drug with other aminoglycoside antibiotics.