Poludan - pharmacological agents from the group of immunostimulants in the treatment of viral diseases of the eye.
Structure and Composition
According to the instructions Poludan available as a lyophilisate for solution. Active substances - potassium poliriboadenilat (0, 1 mg) and potassium poliribouridilat (0, 107 mg). Also includes auxiliary components (sodium hydrogenphosphate, potassium dihydrogenphosphate, sodium chloride).
Externally Poludan a white lyophilizate.
Produced the drug in 1 ml ampoules or vials of 5 ml. The carton 10 ampoules or vials, as well as instructions for use. The pack with ampoule ampoules put a knife or lancet.
Pharmacological action Poludan
According to the instructions Poludan has immunostimulatory effects. This drug is a complex biosynthetic poliribonukleinovym, it increases the synthesis of endogenous interferon.
Poludan has antiviral and immunomodulatory effects, increases the activity of immune cells. Subconjunctival injection of the drug increases the production of interferon in the tear fluid and blood serum.
According to the instructions Poludan recommended for the treatment of viral eye diseases in adults and children, such as:
- herpetic keratoconjunctivitis;
- adenoviral keratoconjunctivitis;
- keratitis and keratoiridotsiklit;
- stromal keratitis, iridocyclitis;
- optic neuritis.
The drug is contraindicated in case of hypersensitivity to its components.
Introduction Poludan not recommended for keratouveitis ulcerated cornea (anterior surface) and conjunctivitis with the presence of pathogenic organisms in crop conjunctiva. The drug is not to be administered for infections of the paranasal sinuses (sinusitis, sinusitis, etc.) And teeth.
Instructions Poludan: Dosage and administration
According to the instructions Poludan introduced subkonyunktivalno, periocular and into the anterior chamber of the eye.
Pre-drug can be dissolved in 1 ml of sterile water for injection or in the same amount of 0, 5% novocaine solution. Poludan injected under the conjunctiva in a day or a day, 1 time per day. The duration of treatment is 5-20 days (determined individually for each patient).
Children enter advised Poludan subkonyunktivalno to 0, 25 ml a day. The duration of treatment is 8-10 days.
When herpes keratoiridotsiklite (endothelial form) Poludan solution should be administered according to the instructions in the anterior chamber of the eye using a tuberculin syringe into the operating room. The volume of injected drug - 0, 3-0, 6 ml, the drug is administered twice a week for a course requires 3-5 injections.
When herpes chorioretinitis, uveitis, optic neuritis on instructions should be introduced Poludan periocular (retrobulbar, parabulbarno) 1 ml, 1 time in 2 days (after the lyophilisate is dissolved in 1 ml of water or a solution of novocaine 0, 5%).
In the case of fresh herpes zoster rash on the face, and while herpetic lesions of the cornea, carry out subcutaneous injection of the drug. To this vial 2 is dissolved in 10-20 ml of novocaine (0, 5%) and are given subcutaneous injections during herpetic vesicles. The procedure is performed in a day. Such use Poludan, reviews, effectively reduces pain and promotes rapid healing. In the course of 3-6 treatments is required.
Side effects Poludan
In the opinion of Poludan rarely causes allergic reactions. When subconjunctival injection of the drug may appear slight swelling in the area of the lower eyelid and conjunctival vascular injection worsen. If Poludan injected into the anterior chamber of the eye, it is possible transient increase in intraocular pressure and the appearance of petechial hemorrhages in the anterior chamber of the eye.
Interaction with other drugs
Not recommended for use together with enzyme Poludan medicaments, as they contribute to the destruction of endogenous interferon, and thus reduce the effectiveness of the drug.
According to the instructions Poludan well with antibacterial and antiviral drugs.
Special instructions for use Poludan
Adverse reactions that occur when administered Poludan, reviews, are short-term transient and disappear after the abolition of the drug in 1-3 days.