Phenazepam - a highly tranquilizer, has anxiolytic, anticonvulsant, muscle relaxant and sedative central action. Tranquilizing and anti-anxiety effect is superior in strength fenazepama counterparts. Also, the drug has antispasmodic and sedative effect. Anxiolytic effect of the drug is expressed in reducing the emotional stress, reducing the fear, anxiety and worry.
According to the feedback received Phenazepam virtually no effect on the affective, hallucinatory and delusional disorders sharp.
Phenazepam Dosage and instructions for use
Intramuscular and intravenous: for quick relief of agitation, anxiety, fear, as well as psychotic states and autonomic paroksizmah- initial dose to 1 mg, mean dose per day -3-5 mg maximum - 7-9 mg.
Oral: sleep disorders, from 250 to 500 mg, 20-30 minutes before bedtime. In the treatment of psychotic, neurotic, neurosis and psihopodobnymi states, the first dose of 1 mg, 2-3 times a day. The dosage may be increased after 2-4 days, with a positive effect up to 4-6 mg per day. When the expression of fear, agitation, anxiety pervayadoza is 3 mg per day, with the rapid build-up to achieve a therapeutic effect. In the treatment of epilepsy 2-10 mg sutki.Pri treatment of diseases with muscular hypertonicity take 2-3 mg 1-2 times a day. The maximum dose - 10 mg / day.
In order to prevent the acquisition, depending on the fenazepama instruction it is recommended that therapy did not last more than two weeks. In exceptional cases, may increase the duration of the course to 2 months. Reduced dosage should be gradual.
Phenazepam shown in neurotic, neurosis, psychopathic and psihopodobnymi states. When reactive psychosis, senesto, hypochondriacal disorders, insomnia, alcoholism, substance abuse, status epilepticus, epileptic seizures.
It is recommended as a means to overcome the fear and emotional stress in extreme situations. In schizophrenia, with high sensitivity to antipsychotic medications.
For the treatment of muscle rigidity, hyperkinesias, athetosis, tic, vegetative lability.
- myasthenia gravis;
- Severe depression;
- angle-closure glaucoma;
- analgesic poisoning or acute alcohol poisoning;
- acute respiratory failure;
- I trimester of pregnancy;
- Children up to 18 years;
- intolerance benzodiazepines.
Caution is required when applying fenazepama patients with hepatic or renal insufficiency, persons prone to substance abuse, with organic brain damage, elderly patients.
A similar analogy, Phenazepam can cause drug dependence in the long-term therapy with high doses. During the treatment fenazepama strictly prohibited the use of ethanol. On the treatment of persons under 18 years fenazepama No comments, efficacy and safety has not been established. Phenazepam affects concentration, therefore requires special care when driving a vehicle to persons receiving treatment fenazepama.
Overdose symptoms fenazepama: reduced reflexes, somnolence, tremor, nystagmus, dysarthria long, shortness of breath or difficulty breathing, bradycardia, coma, lowering blood pressure.
For treatment of overdose fenazepama recommended administration of activated charcoal, gastric lavage, administration of flumazenil (in hospital). Hemodialysis - ineffective.
Interaction with other drugs fenazepama
According to reviews Phenazepam has reduced effectiveness of levodopa in patients with Parkinson's disease. Phenazepam increases the toxicity of zidovudine.
It noted mutual enhancing effect in combination with antipsychotics, antiepileptics, and hypnotics, and with the central muscle relaxants, narcotic analgesics and ethanol.
When combined with antihypertensive agents may enhance their actions. At the same time taking clozapine possible respiratory depression.
Pregnancy and lactation
Application fenazepama pregnant women is permissible only for health indicators. The drug has toxic effects on the fetus, increasing the risk of birth defects when used in the first trimester of pregnancy. Application fenazepama at a later date is a newborn central nervous system depression. Regular intake during pregnancy may develop dependence and withdrawal symptoms in the newborn.
Application fenazepama during childbirth, or directly in front of them, may be the cause of the newborn: respiratory depression, hypotension, and hypothermia.
Side effects fenazepama
On the part of the central and peripheral nervous system: in the first days of admission (particularly in elderly patients) - fatigue, confusion, drowsiness, dizziness, ataxia, decreased concentration, disorientation, slow reactions; rarely - depression, euphoria, headache, tremors, loss of coordination, memory loss, involuntary movements, fatigue, dysarthria, myasthenia gravis, seizures (in patients with epilepsy); rarely - aggressive outbursts, fear, agitation, suicidal tendencies, muscle spasms, hallucinations, irritability, agitation, insomnia, anxiety.
From the circulatory system: leukopenia, agranulocytosis, neutropenia, thrombocytopenia, and anemia.
From the digestive system: heartburn, vomiting, diarrhea or constipation.
Allergic reactions such as itching or skin rash.
Other possible reactions: like its counterparts Phenazepam gives rise to drug dependence, decrease in blood pressure; rarely - blurred vision, tachycardia. With a sharp lifting or lowering the dose - the appearance of withdrawal symptoms.