Osteogenon - means of regulating the calcium-phosphorus metabolism in bone tissue.
Structure and Composition
The drug is released in the form of oblong, biconvex tablets light yellow color. Each tablet contains:
- active ingredient - ossein hydroxyapatite compound - 830 mg;
- Auxiliary components: potato starch, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.
10 pieces in blister packs.
Osteogenon analogues are the following drugs: Growth-Rate and Osteobios.
Osteogenon - a drug that affects bone mineralization. It contains the components required for the synthesis of bone has on bone metabolism double effect: inhibits osteoclasts and stimulates osteoblasts.
The preparation contains calcium in the form of hydroxyapatite, so it is better absorbed from the gastrointestinal tract. Application Osteogenon inhibits hormone due to bone resorption, inhibits the production of parathyroid hormone. Due to a delayed release of calcium hydroxyapatite no peak hypercalcemia.
Due to phosphorus is involved in the crystallization of hydroxyapatite, the fixation of calcium in the bones and slows down its excretion by the kidneys.
Also in the presence of an organic drug component - ossein, which provides local controllers remodeling of bone tissue (collagen type 1, osteocalcin, β-transforming growth factor, insulin-like growth factors I and II). Through the application of ossein Osteogenon inhibited bone resorption and promotes bone formation.
Insulin-like growth factors I and II contribute to the synthesis of osteocalcin and collagen.
β-transforming growth factor increases the number of osteoblasts enhances their activity to inhibit the formation of osteoclast precursors and enhances collagen.
Collagen type 1 contributes to the formation of bone matrix.
Osteocalcin crystallization stimulates bone by binding calcium.
According to the instructions Osteogenon appoint:
- for the treatment and prevention of primary osteoporosis (senile, menopausal, premenopauznom);
- for the treatment and prevention of secondary osteoporosis of various genesis (caused by hyperthyroidism, hyperparathyroidism, kidney or liver disease, rheumatoid arthritis, osteogenesis imperfecta, immobilization, heparin, corticosteroids);
- for correcting violations calcium-phosphorus metabolism and osteopenia, including during pregnancy and lactation;
- to accelerate healing of bone fractures.
Dosing and dosing regimen Osteogenon
According to the instructions Osteogenon intended for ingestion.
In osteoporosis adults take from two to four tablets twice a day. In other indications the standard dosage is 1-2 tablets twice a day.
The duration of treatment is determined individually depending on the condition and the patient.
Osteogenon of instruction is contraindicated in:
- hypersensitivity to the drug;
- severe hypercalciuria.
No reviews Osteogenon regarding overdose has been reported.
In the opinion of Osteogenon may rarely cause allergies. With prolonged use Osteogenon or its analogs may develop hypercalcemia or hypercalciuria.
Application Osteogenon during pregnancy and lactation
In the opinion of Osteogenon not cause adverse effects on the fetus. Assigned only by the physician.
Osteogenon and its analogs inhibit the absorption of iron and tetracycline antibiotic group, so while admission is recommended that the interval between a minimum of 4 hours.
In combination Osteogenon or its analogs with thiazide diuretics or vitamin D should take into account the risk of hypercalcemia due to increased resorption of calcium.
Osteogenon Review can be taken in patients with hypertension, as it consists of small amounts of sodium chloride.
It is necessary to adjust the dosing regimen osteogenon and its analogues in patients predisposed to kidney stones, depending on the laboratory parameters.
Allowed long-term use of the drug in high doses in patients with impaired renal function.
The shelf life
Subject to the conditions of storage the expiry date Osteogenon according to the instructions of four years.