Omeprazole - a synthetic anti-ulcer drugs to reduce the secretion of gastric glands.  Omeprazole

Pharmacological action

Omeprazole reduces the secretion of gastric glands and, as a prodrug has an effect regardless of the nature of the stimulus.

According to responses Omeprazole has antisecretory effect during the first two hours after ingestion.

Product form

Omeprazole as enteric release capsules containing 20 mg of active substance.

Also produces a number of omeprazole analogues that contain the same active ingredient. These include medicines Sandoz Omeprazole, Omekaps, Omeprus, Romesek, omeprazole, ICCO, Promez, Omefez, omeprazole, Acre, Otsid, Omizak, omeprazole, NS., Omitoks, soprano, omeprazole Richter, Ultop, Helitsid, Omeprazol- PVD Omipiks, Pleom-20 Ulkozol, Tsisagast.

Indications Omeprazole

According to the instructions Omeprazole used to treat:

  • Gastric ulcer and 12 duodenal ulcer, including therapy for relapse prevention;
  • Reflux esophagitis;
  • NSAID-induced gastropathy;
  • Hypersecretory conditions - multiple endocrine adenomatosis, Zollinger-Ellison syndrome, systemic mastocytosis, stress ulceration of the gastrointestinal tract.

In a combination therapy drug omeprazole and analogues are used for the eradication of Helicobacter pylori in gastric ulcer and 12 duodenal ulcer.

In addition, indications Omeprazole is used during general anesthesia as the prevention of aspiration of acidic stomach contents into the respiratory tract.


Omeprazole according to the instructions contraindicated in children, during lactation, as well as existing hypersensitivity to the active or auxiliary ingredients.

Use of omeprazole during pregnancy is possible only with caution under medical supervision. Also, caution should be taken with omeprazole in hepatic and renal failure.

Dosing omeprazole

Omeprazole is recommended to take in the morning, preferably in the morning, regardless of the meal.

Omeprazole in the treatment of peptic ulcer in the acute phase, as well as NSAID-gastropathy and reflux esophagitis take one capsule once a day, and in severe reflux esophagitis, increase the dose twice. The length of treatment varies from two weeks to two months depending on the disease and the therapeutic effect.

When Zollinger-Ellison usually take three capsules of omeprazole maximum - 120 mg per day, divided into several times.

To prevent Mendelson's syndrome, an hour before the operation take 2 capsules of the drug.

For Helicobacter pylori eradication using combined "triple therapy", while taking omeprazole, amoxicillin and clarithromycin.

According to the testimony of omeprazole analogues of the drug can be replaced as a lyophilisate for solution for infusion - Ultop, Helitsid, Zhelkizol, Ulkozol, Losek.  Omeprazole produced in the form of capsules

side effects

The most common disorders of the digestive system caused by omeprazole reviews include:

  • Diarrhea or constipation;
  • Nausea;
  • Flatulence;
  • Taste disturbances;
  • Abnormal liver function;
  • Stomatitis;
  • abdominal pain;
  • Vomiting;
  • Dryness of the oral mucosa;
  • Hepatitis B, which can occur with previous severe liver disease.

Furthermore, omeprazole Review may cause other undesired effects:

  • Thrombocytopenia, leukopenia, encephalopathy, agranulocytosis, pancytopenia;
  • Peripheral edema;
  • Increased sweating;
  • Arthralgia, myasthenia, myalgia;
  • Blurred vision;
  • Gynecomastia;
  • Photosensitivity, rash, erythema multiforme exudative, pruritus, alopecia;
  • Interstitial nephritis, fever, anaphylactic shock, urticaria, angioedema,
  • Malaise.

In cases where the disease is accompanied by severe somatic disease with omeprazole may develop dizziness, agitation, depression, and headaches.

Do not exceed the therapeutic dose of omeprazole to avoid overdose, which can lead to drowsiness, confusion, arrhythmias, blurred vision, headache, nausea, dryness of the oral mucosa, tachycardia.

storage conditions

Omeprazole belongs to the anti-ulcer drugs, prescription, with a recommended shelf life of 24 months.