Normodipin - pharmacological agents from the group of calcium channel blockers used for the treatment of hypertension.

Structure and Composition

 Normodipin available in tablets of 5 and 10 mg. The active ingredient - amlodipine. Besides it the product contains auxiliary components (microcrystalline cellulose, magnesium stearate, dicalcium phosphate anhydrous, sodium carboxymethyl starch).

Tablets normodipin oval, biconvex, white. Produced the drug in blister packs of 10 tablets. One package contains 3 blister normodipin and instructions for use.

Pharmacological action normodipin

According to the instructions, normodipin blockers refers to the "slow" calcium channels of the second generation .  This drug has antianginal and hypotensive action .  Antianginal normodipin due to the expansion of the arteries (including coronary) .  Thus, drug for angina and infarction improves the nutrition reduces the need for cardiac muscle oxygen .  Normodipin hypotensive effect caused by expansion of peripheral vascular .  This drug has a long hypotensive effect, which depends on the dose .  Single dose normodipin Stability lower blood pressure for up to 24 hours .  The onset of action of the drug occurs within 2-4 hours after administration .  Additionally the medicament reduces the severity of left ventricular hypertrophy, without causing reflex increase in heart rate, prevents platelet aggregation and has a weak diuretic effect .

According to the instructions, normodipin no negative impact on the metabolism and lipid content in the blood serum, and can be used in patients with diabetes mellitus, gout and asthma. It is known that food intake has no effect on absorption normodipin.

Withdrawal of the drug primarily by the kidneys (70%), and through the intestines. The period of its half-life is about 45 hours.

Normodipin penetrates the blood-brain barrier. In hemodialysis drug is not removed.


Normodipin recommended to be used for the treatment of hypertension (both as monotherapy and as part of an integrated treatment), stable angina and Prinzmetal angina.

Contraindications normodipin

  • hypersensitivity to the ingredients of the drug;
  • hypotension;
  • aortic stenosis (clinically significant);
  • cardiogenic shock, collapse;
  • unstable angina (except Prinzmetal angina is);
  • age 18 years;
  • pregnancy and lactation.

Precautions should be prescribed the drug in the human liver, with sick sinus syndrome, as well as in severe heart failure.

According to the instructions, normodipin should be used with caution in patients with recent acute myocardial infarction.

Dosing and Administration

According to the instructions normodipin, the starting dose for the treatment of hypertension and angina - 5 mg per day (one drug is taken once a day). If necessary, the daily dose may be increased to 10 mg (1 per day). Maintenance dose in hypertension is usually 5 mg per day.

In patients with renal insufficiency dose adjustment is required.

Side effects normodipin

In the opinion of normodipin well tolerated and rarely causes side effects. Common side effects may occur at the beginning of treatment with this drug and tested over time.

Cardio - vascular system may cause palpitations, peripheral edema, hot flashes and feeling to the skin. Very rarely normodipin, reviews, can lead to excessive low blood pressure, arrhythmia, orthostatic hypotension, and worsening of congestive heart failure.

From the nervous system may cause headaches, dizziness, drowsiness and fatigue. In the opinion of normodipin very rarely may cause asthenia, paraesthesia, tremor, insomnia, mood lability.

On the part of the gastrointestinal tract the drug can often (1-5% of cases) cause nausea, abdominal pain, dryness of mucous membranes of the mouth.

In the opinion of normodipin rarely contribute to the emergence of increased appetite, pancreatitis and hepatitis.

On the part of hematopoiesis rarely observed the development of leukopenia and thrombocytopenia.

From the urinary system normodipin of reviews in rare cases can cause frequent urination, nocturia (nighttime urination more frequent), impotence.

Allergic reactions to this drug is uncommon, may cause itching and rashes. In rare cases, a crane angioedema and urticaria.


Symptoms of overdose normodipin are marked lowering of blood pressure, tachycardia (rapid heart rate). Treatment of overdose is reduced to a gastric lavage, purpose enterosorbents (activated carbon, polifepam) and symptomatic therapy. Good effect of calcium supplementation administered intravenously. Hemodialysis in overdose normodipin not effective.

Interaction normodipin with other drugs

According to the instructions normodipin can be combined with thiazide diuretics, α-blockers, ACE inhibitors. Also, this drug is well combined with nitrates.  Amlovas - similar normodipin

Simultaneous treatment with NSAIDs (nonsteroidal anti-inflammatory drugs), hypoglycemic drugs and antibiotics are not contraindicated.

Application normodipin with lithium therapy may lead to increased neurotoxicity latter. Calcium can reduce the effect of normodipin.

Normodipin not affect the pharmacokinetics of the drug warfarin and both can be used simultaneously.


According to the instructions normodipin necessary to dynamically control the body weight of the patient. In the treatment with this drug should be limited sodium intake (in particular - salt) and comply with an appropriate diet.

In addition it requires the dentist to monitor hygiene of teeth and gums.

Patients with low body weight may require a smaller dose.

Discontinuation should be implemented gradually normodipin (gradually reducing the dose of the drug).

About of normodipin the ability to drive vehicles are not reported. However, please note that individual patients may occur drowsiness, dizziness and other adverse reactions of the nervous system.

Analogs normodipin

Normodipin analogues are drugs from the group of calcium channel blockers on the basis of amlodipine. These include the following drugs: amlodipine Amlodipine-probability, Amlovas, Amlodhi, Amlodifarm, Amlong, Amlotop, cardilopin, Korvadil, Norvasc, Tenoks, Kalchek.

Before replacing analogue normodipin consult with your doctor.