Nevigramon - pharmacological agents from the group of antimicrobial agents belonging to the fluoroquinolones.

Structure and Composition

 According to the instructions nevigramon contains the active substance - nalidixic acid (500 mg) and auxiliary components (colloidal silicon dioxide, stearic acid, quinoline yellow, titanium dioxide, gelatin). Produced nevigramon 500 mg hard gelatin capsules yellow. The polystyrene vial 56 capsules of the drug.

Pharmacological action nevigramon

This drug is bacteriostatic, bactericidal and antibacterial action. Especially nevigramon expressed antimicrobial action against Gram-negative bacteria (including Proteus, Enterobacter, Klebsiella). Active substance formulation partially inhibits DNA synthesis microorganisms thus exerting a bacteriostatic or bactericidal action (depending on the drug concentration and the degree of sensitivity of the bacteria).

Once inside nevigramon rapidly absorbed from the digestive system, the drug is partially metabolized in the liver. Bioavailability is high - 96%. Nevigramon displayed mainly kidneys. It is known that the drug crosses the placental barrier and passes into breast milk.


Nevigramon recommended use for the treatment of infections of the urogenital system (pyelonephritis, urethritis, cystitis, prostatitis), as well as some digestive tract infections that are sensitive to the drug (cholecystitis et al.).

According to the instructions nevigramon recommended to prevent infections after surgery in the kidney, bladder and ureters.

Contraindications nevigramon

Hypersensitivity to the components of the drug, Parkinson's disease, epilepsy, pronounced cerebral atherosclerosis, renal / hepatic insufficiency, porphyria, deficiency of the enzyme glucose-6-phosphate dehydrogenase, children up to 12 years, the first trimester of pregnancy, breast-feeding.

Precautions Nevgramon assigned patients aged 12 to 18 years.

Use during pregnancy and lactation

There have been no clinical studies on the safety of nevigramon during pregnancy. It is known that nalidixic acid crosses the placenta and has an effect on the developing cartilage, so the use of the drug in the first trimester of pregnancy and during the last month before childbirth is prohibited. In other cases, the appointment nevigramon possible if the potential benefits of the drug exceeds the risk.

According to the instructions nevigramon it gets into breast milk, therefore its use is contraindicated during lactation.

Instructions nevigramon: Dosage and administration

The average daily dose for adults is 4 g (2 capsules 4 times a day). The course of treatment should be at least a week.

If needed continue treatment nevigramon after 7 days, the dose can be reduced to 500 mg four times per day.

Children 12 years (with the proviso that their weight over 40 kg) the daily dose is 50 mg / kg (divided into 3-4 doses).

According to the instructions, you need to take into nevigramon for 1 hour before meals.

Side effects

Nevigramon, reviews rarely can cause side effects. The nervous system can be observed weakness, drowsiness, dizziness, headaches. There is evidence that in rare cases can cause psychosis, seizures, and increased intracranial pressure (usually occurs when predisposing diseases of the nervous system). The literature describes isolated cases of paralysis of the sixth cranial nerve. The exact mechanism of this reaction has not been elucidated, but it is known that these symptoms disappear after drug withdrawal.

According to reviews, nevigramon can cause side effects vision - blurred vision, difficulty in focusing, double vision. There is also information about violation of color. These reactions take place after the drug or reducing its dose.

There may be allergic reactions as hives, itching, rash, eosinophilia in the peripheral blood. Rarely nevigramon cause angioedema or anaphylactic reactions.

On the part of the digestive tract nevigramon can cause nausea, vomiting, diarrhea.

In the opinion of nevigramon can in rare cases cause photosensitivity reactions (the appearance of bubbles and redness of the skin from sunlight).

Also very rarely, the preparation may contribute to the development of metabolic acidosis, cholestasis, thrombocytopenia, leukopenia.

Overdose nevigramon

In the event of patient doses that exceed recommended, you may experience nausea, vomiting, lethargy. Also it can be observed an increase in intracranial pressure, psychosis, seizures, metabolic acidosis.

In case of overdose with this drug requires inpatient treatment (symptomatic and supportive therapy).

Interaction with other drugs

According to the instructions, nevigramon enhances the action of oral anticoagulants (warfarin). If you want to co-administration of these drugs, you should monitor the INR or prothrombin index (may require dose adjustment of anticoagulant).

Application nevigramon against other antibacterial drugs (tetracycline, chloramphenicol, and others.) Can weaken its effect.  Blacks - similar nevigramon

Special instructions for use nevigramon

In experiments on animals showed that nevigramon may cause the occurrence of erosions in joint cartilage and promote the development of arthropathy (especially in animals have not reached sexual maturity). Therefore, caution should be used this drug in patients under 18 years and in case of joint pain should immediately stop taking it.

Should inform patients about the need to avoid direct sunlight on the skin during treatment nevigramon. In the case of photosensitive reactions requires removal of the drug.

Effects on ability to drive vehicles and other mechanisms

During the reception nevigramon should be careful while driving or working with moving machinery.

Analogs nevigramon

Analogues are drugs nevigramon blacks and Nalidixic acid. The active ingredient in these formulations is the same, replacing analogue nevigramon require specialist advice to clarify the dose.