Negrustin - herbal drug with antidepressant pharmacological effect.
Structure and Composition
Negrustin issued in the form of gelatin capsules for oral administration. In 1 capsule contains a dry extract of St. John's wort herb (425 mg) and auxiliary components (lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, calcium hydrogenphosphate dihydrate, magnesium stearate, talc, sodium dodecyl sulfate, gelatin, water).
Negrustin performed in polypropylene blisters (10 capsules), in a package can be 3, 6 or 10 with drug blisters.
Pharmacological action Negrustina
According to the instructions Negrustin has a sedative and antidepressant action, which are caused by St. John's wort content of biologically active substances (gipertsina, hyperforin, flavonoids). These substances have a positive effect on the functional state of the nervous system that leads to improved mood, normalizes sleep, and improves physical and mental activity of the patient.
According to the instructions Negrustin recommended for psycho-vegetative disorders that are accompanied by a bad mood, apathy. The drug is also indicated for use in neurotic reactions, depression (mild to moderate severity). Negrustina allowed to use in conjunction with other psychotropic drugs.
Hypersensitivity to the drug, severe degree of depression, hypersensitivity to ultraviolet, children under 12 years.
Use during pregnancy and lactation
According to the instructions Negrustina its use during pregnancy and lactation is contraindicated.
Dosing and Administration Negrustina
This drug is taken orally, without chewing and drinking water. It is recommended to take 1 capsule 1-2 times a day. The course of treatment is 6-8 weeks Negrustinom. Repeat courses is possible only after consulting your doctor. In the opinion of Negrustin it has an effect after 1-2 weeks from the start of the reception.
In the opinion of Negrustin rarely causes allergic and dyspeptic (nausea, diarrhea) reaction. In fair-skinned patients may photosensitivity reactions (sensitivity to light).
When high doses of the drug may cause adverse reactions. In this case, take chelators (activated carbon, polifepam) cancel Negrustin and avoid exposure to outdoor sunlight. Currently there is no information about the poisoning of drugs based on St. John's wort.
Interaction with other drugs
Use caution while using this drug along with digoxin, theophylline, anticonvulsants and asthma medication.
According to the instructions Negrustin may increase the effects of drugs for general anesthesia and narcotic analgesics.
It is not recommended during treatment Negrustinom taking MAO inhibitors.
In the opinion of Negrustin may weaken the effect of oral contraceptives and may also contribute to inter-menstrual bleeding.
Special instructions for use Negrustina
Patients with fair skin should avoid visiting the solarium, and long-term presence in the open sunlight.
The interval between doses Negrustina and MAO inhibitors should be not less than two weeks.
Do not drink alcoholic beverages during treatment Negrustinom.
This drug has no effect on ability to drive and other mechanisms.