Naloxone - a treatment for poisoning analgesics.

Pharmacological action

Naloxone restores breathing eliminates euphoric, sedative and hypotensive effect of opioid analgesics, so it is used for poisoning by drugs in this group.

Against the effects caused by butorphanol, pentazocine, tramadol Naloxone is ineffective. The action of the drug buprenorphine is also completely eliminated.

After intravenous administration of drug action starts in two minutes, and subcutaneous and intramuscular - 3-5min.

Naloxone Acts 20-45min after intravenous administration, 2 5-3ch after subcutaneous and intramuscular administration.

Product form

Naloxone is released into solution for injection, which contains 0, 4mg active ingredient. It also involves a special form for newborns, which accounts for 1 ml solution 0, 02mg naloxone.

Analogs Naloxone close to him in action: Algisorb, amyl nitrite, Aneksat, Acizol, Braydan, Zoreks, Potassium iodide, carboxy, Lobeline, Lobesil, Nalorfin, Sodium nitrite, Peliksim, pentatech, pentatsina, protamine Tetatsin, Unitiol, ferrocin, Glathion.

Indications Naloxone

The main purpose of the drug - the elimination of the consequences of acute intoxication with narcotic analgesics, barbirutami, benzodiazepines. Naloxone is also indicated in the instructions that it is effective for severe alcohol poisoning, in various states of shock.

Naloxone is also used as a diagnostic tool in patients with suspected drug dependence. For the treatment of drug addiction because of its short action shall be deemed ineffective.

Apply medication after surgery to remove the patient from anesthesia to resume breathing in newborns in cases where maternity administered opioid analgesics.


Naloxone is contraindicated in case of intolerance means. With care it is used during pregnancy, breastfeeding, heart disease, children.

Naloxone can not be combined with opioid analgesics, such as fentanyl, remifentanilom, nalbuphine, butorphanol, pentazocine - it reduces their effect. It is undesirable to use it in conjunction with clonidine - Naloxone reduces its antihypertensive effect.

Also instructions Naloxone stated that his appointment is contraindicated concurrent with preparations containing bisulfite.

Analogs Naloxone is used in cases where the use thereof have contraindications. Be sure to read the instructions analogues Naloxone, because their contraindications and side effects may vary.

Instructions for use Naloxone

Dosage and route of administration depends on the quantity being in body analgesic and the patient's condition.

If poisoning analgesics starting dosage Naloxone is 0, 4-2, 0mg. Enter the tool slowly intravenously (for two or three minutes), under the skin or intramuscularly. If the patient is in critical condition, intravenous administration is preferred. Re-drug is administered every 2-5min. until you catch your breath and come back out. If after administration of 10 mg Naloxone breathing and consciousness is not restored, it is necessary to double-check the data on the cause of the poisoning.

 An analogue of Naloxone - Aneksat
 Treatment of children begin with 5-10mgk dosage per kilogram body weight. If necessary, Naloxone administered repeatedly.

For removal from the anesthesia drug is administered in a dosage 100-200mkg every two or three minutes before waking up the patient's appearance and normal ventilation.

For removing children from anesthesia administered 1-2mkg per kilogram intravenously. If there is no result, Naloxone administered repeatedly - 100mcg / kg every two minutes to restore breathing and the return of consciousness.

Newborns Naloxone administered in a dosage 10mkg / kg. If you have problems breathing in a child provoked opioid analgesics introduced the mother during childbirth, newborn treatment begins with 1-2mkg / kg. If there is no result, the drug is administered again in doses up to 100mcg / kg every two minutes until the return of consciousness, restore breathing. Before the introduction of the drug problems of the child should be removed from the airway.

To determine addiction injected 800mkg Naloxone and observe the patient for symptoms of withdrawal.

side effects

After Naloxone may be vomiting, nausea, tachycardia, seizures and tremors, may increase pressure to stop the heart, effort, sweating.

If the dosage specified in the instructions Naloxone is not broken, the side effects usually do not occur.

In applying the drug after surgery, at doses higher than the minimum, can begin ventricular tachycardia, hypertension, hypotension, agitation, pulmonary edema, atrial fibrillation.

Withdrawal syndrome when drug addiction is manifested as diarrhea, rhinorrhea, sweating, hyperthermia, sneezing, fatigue, vomiting, tremors, spasms in the epigastric nausea.

Newborns may experience cramps, diarrhea, hyperreflexia, vomiting, tremors, irritability, sneezing, hyperthermia.