Monopril - a remedy for hypertension.

Pharmacological action

Monopril - a drug that lowers the pressure of the active substance acts fosinopril (ester).

Additionally Monopril has vasodilator, potassium-sparing, diuretic effect.

The pressure drop in the application Monopril causes change of the circulating blood volume, renal and cerebral blood flow perfusion of skeletal muscles, skin, internal organs, infarction.

Hypertrophy, hypertension, left ventricular therapy reduces its weight, the thickness of the septum. Violations of the metabolic properties of long-term therapy Monoprilom does not. Hypotensive effect begins within one hour, reaches a maximum of c / o 3-6ch retained another day.

Good reviews of the Monopril in the treatment of heart failure - its beneficial effect is due to inhibition of the renin-aldosterone. It has been observed that reduced afterload, preload on the heart muscle.

The ability of the absorbability is unaffected by food, but observed that the use Monopril before meals slows down the process.

Product form

Monopril release tablets.


Monopril according to the instructions indicated for hypertension (as monotherapy or combining it with thiazide diuretics), heart failure in the complex treatment.

Instructions for use Monopril

P  Take Monopril only inside
 rimenyayut Monopril only inside.

Arterial hypertension, treatment is initiated with 10 mg / day. Change dosage may be from 10 to 40 mg / day - depending on hypotensive effect. If the desired effect after treatment is not seen, it is necessary to adopt a thiazide diuretic. In cases where the patient before treatment Monoprilom already started taking diuretics, its dosage should not exceed 10 mg / day, with constant control of the patient.

When chronic heart failure treatment is initiated with 5 mg Monopril 1-2r / h.

If there is no improvement, the dose for Monopril instructions is increased to 40 mg / day (maximum) after one week.

If a patient has impaired kidney function, liver, Monopril dosage change is not necessary, and elderly patients (after 65l) in which susceptibility to the drug is increased, if necessary, reduce the dosage.

Side effects

Monopril may cause orthostatic hypotension, angina, heart attack, heart failure, arrhythmias, palpitations, a hypertensive crisis may provoke a "flushing" to the head, upper body.

There are reviews of Monoprile, causing dizziness, abdominal pain, memory impairment, headache, confusion, drowsiness, paresthesias, weakness, stroke, ischemic disorders, diarrhea, pancreatitis, flatulence, hepatitis, vomiting, glossitis, dry mouth, nausea , stomatitis, constipation, cholestasis, dysphagia, weight change, abnormal function of the prostate gland.

The treatment may also develop lymphadenitis, kidney failure or worsening, shortness of breath, sore throat, nosebleeds, hoarseness, rhinorrhea, bronchospasm, gout. You may see a rash, itching, angioedema.

The instructions Monopril stated that during treatment can vary laboratory parameters: may appear in the urine protein, increase the level of urea, potassium, erythrocyte sedimentation rate, can increase the activity of enzymes, can decrease sodium levels, develop leukopenia, neutropenia, eosinophilia, gipogemoglobinemiya may reduce hematocrit number.

Contraindications Monoprix

Monopril should not be prescribed to patients with an allergic reaction to fosinopril, pregnant women (provokes various malformations of the fetus), lactating women, children up to 18L.

If a pregnant woman has been appointed yet use Monopril should keep under review the level of potassium, the amount of urine, the pressure of a child.

Antacids (simethicone, aluminum hydroxide, magnesium hydroxide, other preparations of this group) reduces absorbability Monopril - should be taken with an interval of two hours or more.

The lithium salts of the combination with the drug accumulates in the blood that can cause overdose. At the same time of their appointment requires a reduction in dosage of Monoprix.

Anti nesteroidy (aspirin, indomethacin, etc.) reduce the hypotensive effect of the drug.

Combining with Monopril diuretkami, subject to a low-salt diet, hemodialysis, should be borne in mind that in the first hour after his admission could be a sharp drop in pressure.

The combination of the drug with the means, biological supplements containing potassium, potassium-containing diuretics (amiloride, triamterene, sporonolakton) can cause hyperkalemia. In most cases, it is observed in patients with heart failure with a concomitant diabetes.

There are also reviews of Monopril-enhancing hypoglycemic effect of sulfonylureas, insulin.

Due to the combination of the drug with immunosuppressants, cytostatics, procainamide, allopurinol may develop leukopenia.

Estrogens inhibit hypotensive effect of the drug, and vice versa, stimulates its preparations for general anesthesia, opioids, other agents with hypotensive activity.