Midantan - synthetic drug used in Parkinson's syndrome, and Parkinson's disease.
The active substance has antiviral Midantan, n-holinoliticheskoe and antiparkinsonian effect and is used for neuroleptic and posttraumatic parkinsonism.
The drug is most effective when rigid akinetic and forms. In hyperkinetic syndrome, manifested as tremors, Midantan affects considerably less.
The therapeutic effect usually occurs quickly, within the first days of the drug.
To enhance the effect Midantan can be combined with other antiparkinsonian agents - L-dopa and anticholinergic.
Midantan produced in the form of orange-coated round tablets odorless. 100 mg of the active ingredient - of amantadine sulfate in each tablet.
Excipients - potato starch, talc, butyl methacrylate copolymer, microcrystalline cellulose, gelatin, lactose monohydrate, povidone, magnesium stearate, croscarmellose sodium, colloidal silicon dioxide, titanium dioxide, orange dye. 10 pieces per pack.
Midantan of instructions used in Parkinson's syndrome, and Parkinson's disease.
According to the instructions Midantan contraindicated to apply at:
- Hepatic Insufficiency;
- Heart failure II-III degree;
- Concomitantly with triamterene and hydrochlorothiazide;
- Angle-closure glaucoma;
- Chronic renal failure;
- Hypersensitivity to the Midantan;
- Delirious psychosis;
- Prostatic hyperplasia.
Instructions for use Midantan
Midantan instructions for use inside. In Parkinson's disease the drug is used:
- The first three days - in a daily dose of 100 mg. Observe interval between doses of 6 hours, with the last dose is recommended to take a pre-dinner;
- The next three days - 200 mg per day;
- During the second week of treatment the daily dose is 300 mg;
- On the third week, the dose can be increased to 400 mg Midantan maximum - up to 600 mg.
If the kidney function, as well as in the elderly require a dose adjustment and the interval between doses of the drug.
In an application Midantan with drugs that stimulate the central nervous system and ethanol increases the risk of side effects.
In the opinion of Midantan may cause the following side effects - motor or mental stimulation, headache, seizures, insomnia, dizziness.
Violations of the cardiovascular system, in the opinion of the midantanom may manifest as irritability, tremors, mental disorders, which are accompanied by visual hallucinations, and tachycardia, heart failure, orthostatic hypotension, and arrhythmogenic effect.
Other side effects such as anorexia, dermatitis, dry mouth, polyuria, nausea, indigestion, the appearance of a bluish color of the skin of the upper and lower limbs, acute urinary retention in patients with prostatic hyperplasia, nocturia and decreased visual acuity, reviews Midantan is significantly less.
Lactation and the first trimester of pregnancy is a contraindication to the use of Midantan.
The drug is prescribed with caution in orthostatic hypotension, in second and third trimesters of pregnancy, allergic dermatitis, in old age, mental illness and alcoholism.
Midantan released under doctor's prescription and is related to the list B. The shelf life - up to 5 years.