Metipred - hormonal drug.
Metipred refers to hormones from glyukokortikosterodnoy group. Its active ingredient - methylprednisolone.
Step metipred based on interaction with steroid receptors, inhibition of production of proteins, enzymes that participate in the destruction of joints and cytokines involved in inflammatory and immune processes.
Metipred reduces the mechanical response of tissues, infections, heat, immunological, chemical irritants.
Compared with the anti-inflammatory effect of hydrocortisone after receiving metipred five times higher.
Women who take metipred during pregnancy and who have seen a surplus of male hormones (hyperandrogenism), a drug can align hormones.
Anti-inflammatory effect lasts metipred 18-36ch.
Producing a powder depot suspension, tablets metipred.
Metipred according to the instructions shown in rheumatic autoimmune diseases, allergic reactions (including anaphylaxis), asthma, other respiratory diseases (lower) tract, ulcerative colitis, nonspecific, multiple sclerosis.
Applied also to patients with cerebral edema caused by tumors, conditions involving high intracranial pressure, as well as patients during recovery after transplant to prevent rejection.
Admission metipred shown during chemotherapy - both antiemetic.
Assign metipred during pregnancy with the threat of its collapse, as well as in the diagnosis of congenital adrenal hyperplasia
Instructions for use metipred
Tablets metipred take only inside. They are encouraged to take in the morning, to swallow whole without crushing with liquid. Adults begin treatment with a dose 8-96mg p / day. After the effect will be achieved, tablets metipred take less dosage. As maintenance treatment prescribed 4-12mg one p / day.
For children, the dose selected individually, taking into consideration that prolonged therapy may provoke a delay of growth. To avoid such symptoms as a side effect metipred withdrawal, treatment should be stopped gradually.
In a state of shock, to prevent rejection of the implant formulation is administered intravenously in a volume of not more than 30mg / kg. The drug in dosage greater 1mg / kg administered for 30-60min.
As an antiemetic metipred administered in a dosage of 250 mg for 20 min before the administration of cytostatics.
Children's dosage instructions on metipred is 1-3mg / kg during the day.
Depot suspensions are intended for intramuscular, intraarticular administration. Adults 40-120mg administered intramuscularly once a means 7-28dn. Can be administered intra-articularly 4-80mg once 7-35dn (dosage is calculated based on the size of the joint).
The skin lesions metipred 20-60mg administered in the form of retention enemas - 40-120mg one p / 24-48ch.
Admission metipred may cause nausea, bulimia, pancreatitis, heart failure, thromboembolism, increased pressure, leukocytosis, emotional lability, sores in the gastrointestinal mucosa, esophageal candidiasis, gall bladder perforation (rare).
Also, it may be sleep disturbance, glaucoma, cataracts, osteoporosis, myopathy proximal may worsen schizophrenia, increase intraocular pressure, thinned cornea, sclera, tendon may rupture (or reduce its elasticity).
Also among side effects metipred - fluid retention, sodium, potassium level decrease, slowing growth, hirsutism, weight gain, menstrual disorders, amenorrhea, urticaria, skin atrophy, acne, rashes, itching, changes in reaction to the skin test, immunosuppression syndrome Cushing, relapse of tuberculosis infection.
With a sharp lifting of the drug may have pain in the joints, muscles, can raise the temperature to develop adrenal insufficiency.
Metipred of instruction is not suitable for lactose intolerance, sensitivity to methylprednisolone, chronic bacterial and viral infections, latent, active form of tuberculosis (unless the therapy of these diseases).
Be wary appoint metipred in hypertension, congestive heart failure, diabetes mellitus, pancreatitis, elderly patients, patients with mental disorders, gastrointestinal disease with increased risk of opening the bleeding, perforation, diabetes mellitus, family history of the disease, glaucoma, osteoporosis, violations blood clotting, with hypothyroidism, impaired liver function, with a penchant for thrombophlebitis.
Patients with a predisposition to osteoporosis, for prevention of side effects metipred, you must raise the issue of supplemental bisphosphonates.
Assign metipred during pregnancy only under strict indications, as It increases the probability of death of the child. If the drug is taken during pregnancy planning, with its offensive gradually reduce the dosage. Very cancel if pregnancy occurs metipred impossible. The ability to apply the tool during breastfeeding is discussed in every case individually.