Melitor - drugs that affect the nervous system.

Pharmacological action

Melitor refers to the group of antidepressants, is effective in various depressive states, including under stress, abuse synchronize circadian rhythms (the cyclical fluctuations associated with the change of night and day, and represents the "internal clock"), anxiety.

Melitor helps synchronize circadian rhythms, facilitates falling asleep, sleep stabilizes, it stimulates the production of melatonin (a hormone with antioxidant effect, which regulates the cycle of "waking-sleep").

There are reviews of Melitor, used by patients suffering from depression, they noted an increase in slow-wave sleep phase without changing the rapid phase of sleep.

It is also noted that Melitor stimulates the release of norepinephrine, dopamine in the frontal lobe of the brain.

The drug was investigated in healthy volunteers, whereby it was found that the negative effect on the memory, weight, blood pressure, heart rate, concentration, sexual function, he has not. There are also reviews of Melitor, that it is not addictive, does not cause the development of withdrawal symptoms after therapy.

Maximum concentration of the drug reaches after one, two hours after ingestion.

Active substance means - agomelatine.

Product form

Melitor release tablets.

Indications Melitora

Melitor according to the instructions indicated for the treatment of depression.


Melitor can not be used in case of hypersensitivity, lactase deficiency, congenital galactose intolerance, glucose-galactose malabsorption, severe liver disease.

Also according to the instructions Melitor contraindicated in elderly patients with dementia, nursing, pregnant women, children up to 18L.

CAUTION Be assigning patients after Melitor 65l, those who suffer from mania or hypomania, renal disease, patients abuse alcohol, as well as those who accept hepatotoxic drugs.

Those activities are related with dangerous machinery, driving a vehicle shall comply with extreme caution during therapy Melitor.

Bioavailability Melitor decreases in smoking and use of oral contraceptives, on the contrary, it increases.

Instructions for use Melitora

Melitor intended only for internal use. Swallow the tablets whole, without crushing or chewing.

 Melitor - drugs that affect the nervous system.
 To avoid side effects from the gastrointestinal tract is recommended to take the drug during meals, usually at bedtime. The daily dosage Melitor take at one time.

Adults Melitor for instructions on taking 25mg / day. If after two weeks of treatment, the result is negligible, the dosage was increased to 50mg. Dosage can be varied by the attending physician depending on the condition of the patient. Going through the treatment, patients are recommended to constantly monitor hepatic function: at the beginning of treatment and after a few times at intervals of six weeks (approximately 6, 12, 24ned). Lasts treatment of depression is usually not less than six months.

Side effects

Melitor generally well tolerated, only in some cases develop side effects that disappear after two weeks of treatment.

After initiation of therapy may be nausea, gastralgia, hepatitis, impaired stool, increased liver transaminases, dizziness, paresthesia, visual disturbances, suicidal thoughts nature, migraine, feeling of causeless anxiety, headache, disturbance of sleep, urticaria, erythematous rash, pruritus, myalgia, back pain, fatigue, eczema.

There are reviews of Melitor, that in excess of recommended doses may develop epigastric pain, fatigue, drowsiness, anxiety, agitation (strong excitation, combined with a sense of fear and anxiety), cyanosis (blueness of the skin, mucous membranes), tension, malaise dizziness. In case of overdose, patients should wash the stomach, take chelators, as special antidote in Melitor not.