Luvox - a drug from the group of antidepressants, selective serotonin reuptake inhibition. The active ingredient - fluvoxamine - selectively
blocks uptake of serotonin neurons in the brain. Luvox virtually no effect on the metabolic processes of norepinephrine, has a weak affinity for adrenergic receptors, serotonin, dopamine, histamine and holinoretseptorami. Reviews Luvox by psychoneurologists talk about high efficiency of the drug.
When taken orally, Luvox is well absorbed in the gastrointestinal tract. It has the effect of the first passage through the liver. Bioavailability - 53%. Mode meal no effect on the absorption rate of Luvox, as well as its bioavailability. Maximum plasma concentration is reached after 3-8ch after ingestion. Luvox binds to plasma proteins in an amount of more than 80%. It is metabolized in the liver.
The half - 13-18 hours. In the form of metabolites excreted by the kidneys.
In the pathology of the liver drug metabolism slows down.
The instructions to Luvox indicated that the drug is used for different etiology of depression, obsessive-compulsive disorders.
Luvox is intended for oral administration. Tablets should be swallowed whole, not crushed. The maximum daily dose - 300 mg. The daily dose is usually given at one time. The drug is recommended to take in the evening, when the need to separate doses - in the morning and evening. The dosage and duration of therapy in each case determined by the physician.
Average daily dosage in the treatment of depression in adults is 50-100 mg. In case of insufficient therapeutic effect of the dosage is increased gradually. At achievement of clinical effect for the prevention of recurrence it is recommended to continue treatment for at least six months.
Dosage of Luvox for the prevention of recurrence in the treatment of depressive disorders is 100 mg.
The dosage for the treatment of obsessive-compulsive disorder is 50mg. With little effect dosage is increased after 2-3 days. The maximum dosage for this disease also is 300mg.
The daily dosage of Luvox for children 8-18 years of age is 25 mg. With insufficient clinical effect may increase the dosage specified in 2-3 days. The maximum daily dose - 200 mg. If no effect after 10 weeks of drug should be abolished.
According to the instructions, Luvox when liver disease should be prescribed in a minimal clinically effective dose. At higher dosage over several days the patient must be under medical supervision.
The instructions to Luvox contain the following contraindications:
- Individual hypersensitivity to fluvoxamine;
- simultaneous treatment of Monoamine oxidase inhibitors, tizanidine;
- the age of 8 years due to lack of sufficient experience in the use of Luvox in this age category;
- severe renal failure and liver, epilepsy, bleeding tendency.
Side effects Luvox
When you receive this drug may develop a large number of side effects, which often cause negative reviews about Luvox by patients who used the drug. Registered the following side effects of Luvox:
- from the gastrointestinal tract: nausea, vomiting, epigastric pain, impaired appetite, dry oral mucosa, disturbance chair, elevated liver enzymes;
- CNS and peripheral nervous system: headache, weakness, dizziness, agitation, anxiety, tremors, ataxia, disturbance of sleep and wakefulness, extrapyramidal disorders;
- with the CCC: lowering heart rate, heart rhythm disturbances, postural hypotension, palpitations;
- Allergic reactions: rash, pruritus, angioedema, photosensitivity;
- Other: muscle and joint pain, impaired sexual function, increased sweating, galactorrhoea, impaired urination, weight change.
Upon receipt of Luvox and analogs may cause hyponatremia running after drug withdrawal.
It is rarely mentioned the development of serotonin syndrome (muscle rigidity, increased body temperature, changes in the psyche, coma, lability of the autonomic nervous system).
To prevent side effects Luvox should be taken under medical supervision and only if prescribed by your doctor.
Application of Luvox during pregnancy
There is not enough
amount of data on the effect of the drug on the fetus. In cases where the expected benefit to the mother greatly exceeds the possible risks to the fetus, Luvox can be assigned during pregnancy. In therapy Luvox in the III trimester of pregnancy requires careful monitoring of the newborn because of the risk of withdrawal symptoms.
Interaction with other drugs Luvox
The simultaneous use of Luvox and hypoglycemic drugs requires correction of the dosage of the latter.
Contraindications Luvox and analogue reception simultaneously with MAO inhibitors.
The drug alters the pharmacokinetics of terfenadine, cisapride, astemizole, theophylline, Valium, methadone, carbamazepine, phenytoin.
Luvox increases the concentration of caffeine in the blood, warfarin, propranolol, midazolam, ropinirole, diazepam.
Luvox is contraindicated combination with ethanol.
If there are signs of an overdose of Luvox gastrointestinal pathology, cardiovascular system, nervous system: nausea, vomiting, fatigue, sleep disturbances, low blood pressure, cardiac arrhythmias, seizures, liver failure. No specific antidote. It is recommended to wash the stomach, take chelators and symptomatic treatment. Hemodialysis, forced diuresis with an overdose of Luvox is not effective.
Due to the high efficiency of the drug Luvox reviews from doctors positive. Reviews Luvox by patients also talk about good clinical effect of the drug, but in many Luvox side effects, prevent or minimize the development of which can be under constant medical supervision and selection of adequate dosage.
There are the following analogues Luvox: Deprivoks, fluvoxamine.
Luvox drug should be stored at room temperature. The drug should be stored away from sunlight and out of reach of children.
Before using the drug to study in detail the instructions for Luvox.
Luvox and analogues can be used only on prescription.