Lisinopril - a drug designed to lower blood pressure.

Pharmacological action

Representing an angiotensin-converting enzyme (ACE) inhibitor, lisinopril has a pronounced hypotensive (lowers blood pressure) properties.

Valuable as this drug to their cardioprotective (adjust the functional state of the myocardium), a vasodilator and natriuretic (excreted in the urine sodium salt) effect.

Prolonged use of Lisinopril reduces hypertrophy (increase in weight) of the walls of the arteries and the myocardium, improve blood circulation.

Lisinopril reviews and clinical studies described as a drug that has the ability to extend the life of patients suffering from chronic heart failure and prevent the progression of left ventricular dysfunction after myocardial infarction.

Lisinopril takes effect at 1 hour after administration, 4-6 hours - the maximum observed effect of the drug, the total duration of therapeutic effect -24 hours.

When using Lisinopril in patients with hypertension relief of the patient occurs in the first days of taking the drug, and the effect of a stable fixed in 1-2 months.

Indications for use of Lisinopril

Use Lisinopril manual recommends that: the various forms of hypertension, diabetic nephropathy, as well as in combination therapy for early treatment of acute myocardial infarction and chronic heart failure.


These instructions indications for Lisinopril can not be regarded as a guide to self-treatment, since the use of this drug can be dangerous for certain categories of patients.

For Lisinopril is not imposed on persons with hypersensitivity to ACE inhibitors, in particular lizinoprilu, as well as pregnant and lactating women.

Hereditary angioedema and angioedema in history are also a cause for rejection of the use Lisinopril.

Precautions should be taken Lisinopril in diseases such as:

  • aortic stenosis;
  • cardiac ischemia;
  • cerebrovascular diseases;
  • coronary insufficiency;
  • diabetes;
  • suppression of bone marrow hematopoiesis;
  • systemic connective tissue disease severe;
  • hyperkalemia;
  • renal insufficiency;
  • hypotension;
  • primary aldosteronism.

The usefulness of Lisinopril be sure to discuss with your doctor elderly patients and persons who are on a diet with restriction of salt.

Instructions for use Lisinopril

Lisinopril, indications suggest receiving different dosages available in tablets containing 2, 5 mg, 5 mg, 10 mg and 20 mg of the active ingredient. Lisinopril Accept User recommended once daily, preferably at the same time.

To begin the application Lisinopril in essential hypertension should be 10 mg per day, with the subsequent transition to a maintenance dose of 20 mg per day, while in extreme cases, may be receiving the maximum daily dose of 40 mg.

Reviews of Lisinopril suggest that full therapeutic effect of the drug may develop after 2-4 weeks of treatment.

If after applying the maximum doses were not achieved the expected results, it is recommended supplementation with other antihypertensive drugs.

Patients taking diuretics for 2-3 days prior to use Lisinopril should stop taking them. If for some reason it is impossible to cancel diuretics, lisinopril daily dose should be reduced to 5 mg.

If states with increased activity of the renin-angiotensin-aldosterone system, which regulates blood volume and blood pressure, to use Lisinopril manual recommends a daily dose of 2 mg 5-5. The maintenance dose of such drug in the diseases set individually depending on the blood pressure.

In renal insufficiency, the daily dose Lisinopril depends on creatinine clearance and may vary from 2, 5 to 10 mg per day.

Persistent hypertension involves taking 10-15 mg lisinopril daily for a long time.

Taking the drug in chronic heart failure begins with 2 5 mg per day, and after 3-5 days was increased to 5  Lisinopril tablets
 mg. Lisinopril maintenance dose in this disease is 5-20 mg per day.

Use of lisinopril in acute myocardial infarction, and requires combined therapy according to the following scheme: the first day - 5 mg, followed by the same dose - once a day, and then increase the amount of drug in half and take one every two days, the final stage - 10 mg once per day. Lisinopril readings will determine the length of treatment in acute myocardial infarction take at least 6 weeks.

In diabetic nephropathy manual recommends taking Lisinopril 10 mg-20 mg per day.

side effects

The most common adverse effects of the drug Lisinopril reviews include fatigue, headache, dizziness, dry cough, nausea and diarrhea.

According to the instructions, Lisinopril may also cause such side reactions as:

  • chest pain, a significant decrease in blood pressure, bradycardia, tachycardia, palpitations, myocardial infarction;
  • drowsiness, confusion, emotional lability;
  • anemia, thrombocytopenia, neutropenia, agranulocytosis, leukopenia;
  • bronchospasm, shortness of breath;
  • changes in taste, dry mouth, dyspepsia, anorexia, pancreatitis, hepatitis, jaundice;
  • photosensitivity (hypersensitivity to sunlight), hair loss, increased sweating;
  • anuria (absence of revenue urine into the bladder), oliguria (reduced urine output), renal dysfunction, reduced potency, proteinuria (the presence of protein in the urine), uremia (accumulation of urea in the blood), acute renal failure;
  • skin rash, angioedema, fever;
  • neuro-psychological weakness, joint pain, muscle pain, cramps, vasculitis (inflammation and destruction of the vessel wall).

Additional Information

Provided Lisinopril storage in a dark place at room temperature, the drug will be fit for use within three years.