Lerkamen - blocker of slow calcium channels, used in the treatment of diseases of the cardiovascular system.
Pharmacological action Lerkamena
The drug Lerkamen inhibits vascular smooth muscle cells, and transmembrane calcium current in cardiomyocytes, has a prolonged antihypertensive effect and hypotensive effect, thanks to the direct relaxing effect on vascular smooth muscle.
Form release Lerkamena
According to the instructions, Lerkamen produced in the form of biconvex, round, film-coated pale yellow or light yellow tablets, with Valium on one side, light yellow color on a break, in blisters in cardboard packs. One tablet contains 10 mg Lerkamena lercanidipine hydrochloride, 30 mg of lactose monohydrate, 39 mg of microcrystalline cellulose, 15, 5 mg of sodium carboxymethyl starch (type A), 4 Povidone K30 5 mg and 1 mg of magnesium stearate.
The composition of the coating film 3 includes Lerkamena mg Opadry OY-SR-6497, 1, 913 mg of hypromellose, 0, 3 mg of macrogol 6000, 0, 15 mg of talc, 0, 6 mg of titanium dioxide and 0, 037 mg of iron oxide pigment yellow.
Also according to the instructions Lerkamen produced in the form of biconvex, round, film-coated reddish pink tablets with the mark on one side, light-yellow on the fracture in blisters in cardboard packs. One tablet contains 20 mg Lerkamena lercanidipine hydrochloride, lactose monohydrate, microcrystalline cellulose, sodium carboxymethylstarch (type A), povidone K30 and magnesium stearate.
The composition of the film coat Opadry Lerkamena includes 02F25077, titanium dioxide, Macrogol 6000, iron oxide, talc and hypromellose.
The analogue Lerkamena of the active substance is a drug-Zanidip Rekordati.
By analogues Lerkamena mechanism of action and of belonging to a group of pharmacological drugs include:
- Vero Amlodipine;
- Omelar cardio;
- EsKordi Cor.
According to the instructions, Lerkamen prescribed for essential hypertension of mild to moderate severity.
In accordance with the instructions, Lerkamen take 15 minutes before eating in the morning inside, not liquid and abundantly with water. The initial dose is 10 mg, with a gradual increase to 20 mg once a day.
In accordance with the instructions, Lerkamen contraindicated in:
- Hypersensitivity to the drug;
- Aortic stenosis;
- Lactose intolerance, galactosemia, a syndrome of malabsorption of glucose and galactose;
- Chronic heart failure;
- Severe disorders of the liver and kidneys;
- Unstable angina.
Also, the use Lerkamena contraindicated in pregnancy and lactation, during a month after myocardial infarction, children under the age of 18 years and women of childbearing age, not using reliable contraception.
Precautions Lerkamen prescribed for liver and kidney failure, elderly patients with ischemic heart disease and left ventricular dysfunction.
Side effects Lerkamena
Application Lerkamena, reviews, causes side effects of the various systems of the body, namely:
- Peripheral edema, palpitations, tachycardia, lowering blood pressure, chest pain, angina, asthenia, myocardial infarction, fatigue, headache and dizziness (cardiovascular system);
- Dyspepsia, vomiting, reversible increases in liver enzymes, epigastric pain, nausea, diarrhea, and gingival hyperplasia (digestive system).
Also Lerkamen, reviews, sometimes causes polyuria, rash, myalgia and drowsiness.
In accordance with the instructions, Lerkamen must be stored out of reach of children and protected from light, dry place at room temperature up to 30 ° C. Shelf life of the drug in compliance with the recommendations is 3 years.