The drug Lerivon applies to antidepressants and is used for the relief of depressive disorders of various origins. The international non-proprietary name lerivon - mianserin (aka (mianserin) is a pharmacologically active ingredient of the drug).  Lerivon

Product form

Lerivon available in tablets of white color having a film coating of 30 mg per tablet mianserin, 20 tablets per pack. Produced at the facilities of the drug known European pharmaceutical "giants" - the Dutch "Organon." Thanks to this, by the way, acquired a special tablet characteristics: on one side of the tablet by depressions affixed "7 / ST", another - «ORGANON».

The reader may be wondering what other preparations containing inherently mianserin, today in Russia is not registered. So Lerivon within our country can be considered unique in its preparation.

Pharmacological action

Lerivon stimulates noradrenergic transmission of nerve impulses in the brain by blocking the alpha-2 receptor and preventing reverse neuronal capture of neurotransmitter norepinephrine. Why is everyone so "tied" to norepinephrine? The fact that the mediator is the founder of adrenaline, increases the activity of the brain (it, by the way, is called "mediator waking"), which is crucial in the fight against depression. In addition, it has an affinity for serotonin receptors, which is also known as norepinephrine, is shaped name: it is called "happiness hormone".

The drug has the ability to remove the anxiety (the so-called anxiolytic effect), which has been repeatedly confirmed those reviews about lerivon.

Another pharmacological effect lerivon - sedation (calming) - linked to its activity in relation to the alpha-1 adrenergic and histamine H1-receptors.

Based on reviews lerivon, the drug is well tolerated by older people, including those with heart problems. In other words, unlike the tricyclic antidepressants (amitriptillin, Melipraminum) it has no toxic effects on the myocardium in case the patient with the dose overdone.


This chapter may be limited to one word: depression. Succinctly, but corresponds exactly to the true destination of the drug.

Regulations on the use of lerivon

Tablets Lerivon taken without regard to food intake. If there is a need, then washed down with water. Chewable tablets are not worth it.

Regarding the dosing regimen will be appropriate to differentiate according to the age of the patient:

  • adults start with 30 mg per day. The dose is increased gradually until the onset of the most pronounced therapeutic effect. It comes as a rule, in response to receiving 60-90 mg daily;
  • elderly begin with the same 30 mg (or 1 tablet), but for the occurrence of clinical effect is usually enough for them lower dose;
  • Lerivon children and adolescents can not be taken.

The daily amount of the drug, according to reviews of lerivon patients, it is more convenient to take at a time, just before bedtime (remember its sedative effect, which has been written above). The therapeutic effect of the drug is expected in 2-4 weeks. Without waiting for the expected effect - increase the dose. If there is no result after increasing the dose of treatment lerivon stop and pick up some other drug.

The duration of treatment lerivon typically 4-6 months. Ends abruptly antidepressant therapy is not necessary, so as not to get withdrawal symptoms.


Contraindications to receiving lerivon are:

  • intolerance;
  • mania;
  • severe disorders of the liver;
  • childhood and adolescence (up to 18).

Lerivon during pregnancy

Despite the fact that the reviews lerivon as a drug that can cause harm to the fetus or newborn child is not mentioned, it is recommended to use it in pregnant women only when absolutely necessary, for it. The same instructions for lerivon says regarding his reception during lactation.

side effect

From reviews lerivon were derived following possible side effects:

  • dryness of the mouth;
  • long constipation;
  • Accommodative disorders;
  • the emergence of excess body weight;
  • excessive sedation, which extends as far as the continuation of treatment;
  • swelling;
  • granulocytopenia (reduction of granulocytes in the blood) and agranulocytosis (decrease of neutrophils in the blood).

Overdose lerivon identified by persistent sedation. Other typical symptoms of an overdose (cardiac arrhythmia, vomiting, convulsions) are rare. Selective antidote, as such, does not exist. In such situations, do gastric lavage and conduct other standard measures to evacuate the body of excess drug.  Lerivon pills


Lerivon implemented strictly from pharmacies by prescription.

As already mentioned, (the same can be found in the instructions for lerivon) drug categorically not be used in children and adolescents. Experience has shown that in people in this age group is capable of generating Lerivon manifestations of suicidal behavior.

During the reception of the drug should refrain from activities requiring increased attention (driving vehicles, work with potentially dangerous machinery).

Instructions for storage lerivon

First of all, you must exclude the possibility of getting lerivon in children's hands. As for storage, the drug may be stored in a sufficiently wide temperature range: 2 to 30 ° C. Lerivon storage must be protected from sunlight, relative humidity - no more than 80%.

Shelf life Lerivon - 5 years, after which it must be disposed of.