Lantsid refers to clinical and pharmacological group of drugs-inhibitor (H
-ATPase), And anti-ulcer drugs.
International name of the drug - Lansoprazole.
Pharmacological properties Lantsida
As a specific inhibitor of proton pump Lantsid providing blocking effect on the secretion of hydrochloric acid in its final stage, thereby reducing the basal and stimulated secretion regardless of the nature of the stimulus. Lantsidu characterized by a high lipophilicity which facilitates its penetration into the gastric parietal cells. Focusing there, he has a cytoprotective influence enhances the oxygenation of the mucous membrane of the stomach and increases the secretion of bicarbonate.
Deceleration rate of basal and stimulated secretion of hydrochloric acid depends on the dosage of the drug: pH-level increases in one or two hours after taking 15 mg and after two or three hours after ingestion of 30 mg. The dose of 30 mg inhibits production of hydrochloric acid at 80-97%.
Landits no effect on the motility of the gastrointestinal tract.
The inhibitory effect is seen from the increase in the first four days after the start of treatment Lantsidom. Upon completion of acidity for a further 39 hours remains at index not exceeding 50% of the basal level. Secretion is not increased.
Normalization of secretory activity reached 3-4 hours after completing the course of treatment.
Longer Lantsid action has on patients who exhibit Zollinger-Ellison syndrome. This also marked growth inhibition of Helicobacter pylori (this is due to the formation in gastric mucosa specific IgA) and increasing the activity of H. pylori other drugs. As a result of receiving Lantsida increases the concentration of pepsinogen in the blood and inhibits the production of pepsin.
Lantsid is an effective treatment for ulcers that developed in the stomach and duodenum 12, which is resistant to the histamine H
The daily dose is 30 mg taken for 4 weeks, 85% allows for the healing of ulcers in 12 tiperstnoj intestine.
The first receiving 15 mg lansoprazole increases the gastric pH for the first two hours, and the drug in a dosage of 30 mg - already in the first hour. The duration of the effect of more than 24 hours. Stopping Lantsida causes no increase in acidity in the stomach. Hydrochloric acid secretion after administration of several doses of the drug normalized for a period of 2 to 4 days.
Release form and composition Lantsida
Lantsid drug comes in the form of hard gelatin capsules filled with pellets (pellets) of a white or nearly white.
The active substance used lansoprazole which contains one capsule of 15 mg.
Lantsid Available in blister packs of 10 pieces. The carton is 3 blisters.
Appointed for stomach ulcers and 12 duodenal ulcer (in the acute phase), with reflux esophagitis, Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, dyspepsia, ulcerative not wearing character.
Prohibited Lantsid for use:
- in the presence of gastrointestinal malignancies;
- during early pregnancy (first trimester);
- at elevated individual sensitivity to the drug.
With extreme caution Lantsid prescribed for liver failure in the 2nd and 3rd trimesters of pregnancy, patients older and younger than 18 years.
The drug belongs to a group of drugs whose action on the body of a woman during pregnancy has not been studied.
Instructions Lantsida: methods of use
Like most of his peers, Lantsid taken orally before meals (optimally - before breakfast). Capsules swallow without chewing.
In the presence of 12 ulcers and duodenal ulcers stress onetime the drug administered per day in a dosage of 30 mg. Course duration 4-8 weeks.
In gastric ulcer and erosive and ulcerative esophagitis prescribe a one-time daily dosing at a dose of 30 mg. Course duration 4-8 weeks. If necessary, the dose may be doubled (up to 60 mg / day).
Reflux esophagitis requires daily administration of 30 mg Lantsida for 4 weeks.
With Zollinger-Ellison syndrome the drug is dosed individually so that basal acid production did not exceed 10 mmol / hour.
For Helicobacter pylori eradication Lantsid take together with antibiotics (clarithromycin, amoxicillin). The daily dose - 60 mg (30 mg for administration twice a day). Course duration - not less than 7 days.
If not ulcerative dyspepsia character Lantsid take a dosage of 15-30 mg / day for 2-4 weeks.
The old age of the patient and observes his liver failure is a cause to the appointment of a half-dose of the drug. During treatment, the daily dose is adjusted to 30 mg, but should not exceed it.
Instructions Lantsida indicates that at this point if I overdose was not.
Features reception Lantsida
After a course of treatment, according to the instructions Lantsidu, it is absolutely necessary to carry out endoscopy, which would eliminate the malignant neoplasms character. This is due to the fact that the treatment promotes hiding symptoms and delays timely correct diagnosis.
By analogues Lantsida include Akrilanz, Gelikor, Lanzap, Lanzaptor, Lanzabel, Lansofed, Loenzar-sanovel Epicurus, lansoprazole and so on.