Ladisan - tetracyclic antidepressant structure
 Ladisan - an antidepressant.

Structure and Composition Ladisana

Ladisan released in two dosage forms:

  • Round-coated tablets containing 25 or 50 mg of active substance - maprotiline hydrochloride. Additional tablet components are: corn starch, lactose, calcium phosphate, talc, gelatin, colloidal silica, dyes, hypromellose, polysorbate-80. The blister packs of 10 tablets.
  • Colorless transparent solution for intravenous infusion and injection. 1 ml of solution contains 5 mg of maprotiline methanesulfonate. Supporting components of the solution are: water for injection, methane sulfonic acid and mannitol. The colorless glass ampoules 5 ml.

Pharmacological action Ladisana

According to the instructions Ladisan - a drug belonging to the group of serotonin reuptake inhibitors and noradrenaline. Pharmacological action maprotiline (tetracyclic antidepressant structure) is to suspend reverse neuronal uptake of serotonin and norepinephrine neurotransmitters presinopticheskimi membranes of neurons of the cerebral cortex.

This medication is different optimal combination of all principal properties of antidepressants. Application Ladisana uplifting, promotes the disappearance of the excited state and fear, relieves psychomotor retardation and various somatic abnormalities, characteristic of masked depression.

Effective Ladisan pretty quickly, and the therapeutic effect can be observed after only a few days after the start of treatment. In addition, reviews, Ladisan very well tolerated by the body, so is widely used in outpatient practice.

Indications Ladisana

According to the instructions, Ladisan is useful for a variety of depression:

  • somatogenic (symptomatic, organic);
  • endogenous (involution, cyclic, periodic);
  • depression menopause;
  • psychogenic (neurotic, reactive depression exhaustion);
  • masked forms of depression.

Assign Ladisan and other depressive disorders, accompanied by the following symptoms:

  • apathy;
  • irritability or dysphoria;
  • the feeling of fear.

According to reviews, Ladisan positive effect on somatic and psychosomatic disorders arising on a background of fear or anguish.


With care prescribe a drug to patients with impaired liver or kidney disease, with increased intraocular pressure, micturition disorders (eg, in diseases of the prostate).

With prolonged use Ladisana patients should regularly monitor the ECG and heart function. This applies especially to patients who suffer from cardiovascular diseases, and elderly patients. Patients who are prone to orthostatic hypotension, should regularly check your blood pressure while taking the drug.

Note that, like other psychotropic drugs, use of Ladisana reduces tolerance to alcohol.

According to reviews, Ladisan in tablet form may adversely affect the mental and physical reactions, especially if the medication combined with alcohol or drugs, having a depressive effect on the central nervous system.

When using the solution Ladisana possible strong negative impact on the psycho-physical reactions, so the period of treatment, patients are prohibited to drive and operate potentially dangerous machinery.

Dosing and dosing regimen Ladisana

Dosages of drugs are selected individually for each patient depending on the severity of the disease. Allowed to increase or decrease the dosage of the evening by reducing or increasing the daily dose. It is also possible to take the daily dose in one step, preferably in the evening. Upon reaching positive effect you can try to reduce the dosage of the drug, but the manifestation of repeated signs of depression is recommended to return to the previous dose.

Pills Ladisana carried inside. Preferably they are used for outpatient treatment of depression 25 mg to about three times each day or at 25-75 mg dose in the evening. If the depression is severe and the treatment of it is conducted in a hospital, the daily dose may be increased to 150 mg.

The solution is primarily prescribed for svezhevyyavlennyh cases of severe depression or if treatment tablets Ladisan did not bring the desired result. The daily dosage for intravenous drip infusion is 25-100 mg. To prepare the solution needed to dissolve the contents of ampoules of 1-2 in 250 mL solution of glucose or sodium chloride and slowly administered over two hours. If the patient must enter a higher dose of the drug, the infusion increased to three hours.

Typically, after the first two weeks of treatment using Ladisanom infusion therapy of the patient is transferred to oral treatment.


According to the instructions, Ladisan contraindicated in the following cases:

  • Hypersensitivity to the main active component - Maprotiline;
  • acute myocardial infarction;
  • convulsions;
  • first trimester of pregnancy;
  • cardiac arrhythmia.

Application Ladisana during pregnancy and breastfeeding

In the first trimester of pregnancy, the use of drugs is strictly forbidden. Generally, during pregnancy it is not recommended to welcome Ladisana, except for exceptional reasons or in the absence of alternatives.

Because the active component of the drug passes into breast milk, use of the drug at the time of breast-feeding should be discontinued.

side effects

According to reviews, Ladisan in the first days of its use can cause fatigue and anticholinergic effects (constipation, dry mouth, dizziness, disturbance of accommodation). In rare cases, there is tachycardia, and low blood pressure. There may be skin reactions associated with hypersensitivity to maprotilenu requiring discontinuation.


According to the instructions, Ladisan can cause an overdose. Symptoms develop in about four hours after drug administration, reaching a peak after day.

Symptoms of overdose may include:

  • disorders of the cardiovascular system (arrhythmia, tachycardia, cardiac failure, hypotension);
  • agitation or depression of the central nervous system (anxiety, convulsions, drowsiness, muscle rigidity, coma, stupor).

 Ladisan affects the psychosomatic and somatic disorders that occur against a background of fear and anguish
 In rare cases, an overdose can cause vomiting, cyanosis, fever, anuria, oliguria, mydriasis, increased sweating.

In case of overdose symptomatic treatment is necessary to carry out.

Storage conditions Ladisana

Ladisan as a solution and tablets should be stored at room temperature in a dry place inaccessible to children. Shelf life is 5 years.